[A morphological assessment of the efficacy of benzofurocaine in experimental burns]. / Morfologicheskaia otsenka éffektivnosti benzofurokaina pri éksperimental'noi ozhogovoi bolezni.

Studies of the effect of benzophurocaine on the morphological structure of the skin and viscera in animals with burn disease have shown the drug to have a protective action. The latter one manifested itself in a considerable reduction of injuries to the viscera and in a more rapid recovery of the disordered structure and function.

[The anti-arrhythmia activity of quinazopyrine]. / Issledovanie antiaritmicheskoi aktivnosti khinazopirina.

The antiarrhythmic activity of quinasopirine was studied in the experiments on rats with the use of models of calcium chloride- and aconitine-induced arrhythmias, disorders of cardiac rhythm in myocardial infarction produced by isadrine and pituitrin and also in the experiments on cats in arrhythmias caused by electric stimulation of the myocardium, postinfarction and reperfusion arrhythmias. Quinasopirine exhibits the antiarrhythmic effect being superior to that of anapriline and novocainamide in arrhythmias induced by calcium chloride and aconitine. In other types of the cardiac rhythm disorder its activity is comparable with that of ethmosine, obsidane and cordarone. Quinasopirine reduces automatism and contractile function of the myocardium.

[Effect of the autonomic nervous system on the resistance of heart ventricles to fibrillation]. / Vliianie vegetativnoi nervnoi sistemy na ustoichivost' zheludochkov sertsa k fibrilliatsii.

Effects of vagus stimulation and cutting on the tolerance of heart ventricles to fibrillation in cats have been studied. The parasympathetic effects increased the tolerance of heart ventricles to fibrillation while sympathetic ones--decreased it.

[Antifibrillatory activity of anti-arrhythmia agents in maximally high ligation of the coronary artery and its reperfusion in cats]. / Protivofibrilliatornaia aktivnost' nekotorykh antiaritmicheskikh sredstv pri maksimal'no vysokoi pereviazke koronarnoi arterii i ee reperfuzii u koshek.

Experiments on anesthesized cats were performed to study antifibrillatory action of the basic antiarrhythmic remedies and a new Soviet drug, phenicaberan. It was established that phenicaberan and lidocaine compare very favourably with other drugs under study as regards the antifibrillatory effect. For that reason these drugs can be recommended for use in the prophylaxis of fatal arrhythmias.

[Clinical evaluation of the anti-arrhythmic properties and cardiohemodynamic effects of the basic anti-arrhythmia agents]. / Klinicheskaia otsenka antiaritmicheskikh svoistv i kardiogemodinamicheskikh éffektov osnovnykh protivoaritmicheskikh sredstv.

The authors studied the antiarrhythmic and antifibrillatory effects of the known antiarrhythmic agents and the new Soviet coronaroactive drug phenicaberan exhibiting an antiarrhythmic action. All the drugs were examined for side effects and the action on the central and intracardiac hemodynamics in patients with acute myocardial infarction. Recommendations have been given as to the choice of effective drugs for the prophylaxis of arrhythmias depending on the pattern of heart rhythm abnormality and the hemodynamics.

[Effect of cordaron on the threshold of ventricular fibrillation in cats]. / Vliianie kordarona na porog fibrilliatsii zheludochkov serdtsa koshek.

In an experimental study on cats, cordaron administered in a dose of 5 mg/kg significantly increased ventricular fibrillation threshold. Used in a concentration of 1.5 x 10(-6) g/ml, the drug prevented ventricular fibrillation in an isolated heart which had been caused by reduced content of potassium ions and increased content of calcium ions in the perfusate. This action may be due to its influence on myocardial ion transport.

[Comparative characteristics of the experimental antifibrillatory action of anti-arrhythmia preparations]. / Sravnitel'naia kharakteristika protivofibrilliatornogo deistviia nekotorykh protivoaritmicheskikh preparatov v éksperimente.

Effect of lidocain, quinidine, ethmozine, cordaron and obsidan on the ventricular fibrillation threshold was studied in experiments on cats with an opened thorax under nembutal anesthesia. The experiments were carried out on normal animals and animals with acute myocardial infarction exposed to isadrin. Lidocain exerted the most pronounced antifibrillar action in all 3 series of experiments. Ethmozine was most active in animals exposed to isadrin.