The synthesis of N-hydroxy-N'-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells.

We have developed a practical synthesis of N-hydroxy-N'-phenyloctanediamide from the methyl ester of suberanilic acid. It provides the product in high yield and purity with a simple purification process. We have found that at 10(-5) M it has a dramatic effect on T/5 AXC/SSh rat prostate cancer cells in vitro. It is a potent inhibitor of cell proliferation and it changes the cell morphology to resemble nonmalignant cells.

Pancreatitis with pseudocyst and cholelithiasis in third trimester of pregnancy: management with total parenteral nutrition.

Acute pancreatitis with pseudocyst formation during the third trimester of pregnancy was successfully managed conservatively using total parenteral nutrition. We know of no adverse effects on the fetus. The mother was observed until spontaneous delivery and the pseudocyst was subsequently managed surgically. Both mother and infant are well and without unusual sequelae or complications.