Repetition Suppression in Ventral Visual Cortex Is Diminished as a Function of Increasing Autistic Traits.

Repeated viewing of a stimulus causes a change in perceptual sensitivity, known as a visual aftereffect. Similarly, in neuroimaging, repetitions of the same stimulus result in a reduction in the neural response, known as repetition suppression (RS). Previous research shows that aftereffects for faces are reduced in both children with autism and in first-degree relatives. With functional magnetic resonance imaging, we found that the magnitude of RS to faces in neurotypical participants was negatively correlated with individual differences in autistic traits. We replicated this finding in a second experiment, while additional experiments showed that autistic traits also negatively predicted RS to images of scenes and simple geometric shapes. These findings suggest that a core aspect of neural function--the brain's response to repetition--is modulated by autistic traits.

Direct gaze elicits atypical activation of the theory-of-mind network in autism spectrum conditions.

Eye contact plays a key role in social interaction and is frequently reported to be atypical in individuals with autism spectrum conditions (ASCs). Despite the importance of direct gaze, previous functional magnetic resonance imaging in ASC has generally focused on paradigms using averted gaze. The current study sought to determine the neural processing of faces displaying direct and averted gaze in 18 males with ASC and 23 matched controls. Controls showed an increased response to direct gaze in brain areas implicated in theory-of-mind and gaze perception, including medial prefrontal cortex, temporoparietal junction, posterior superior temporal sulcus region, and amygdala. In contrast, the same regions showed an increased response to averted gaze in individuals with an ASC. This difference was confirmed by a significant gaze direction × group interaction. Relative to controls, participants with ASC also showed reduced functional connectivity between these regions. We suggest that, in the typical brain, perceiving another person gazing directly at you triggers spontaneous attributions of mental states (e.g. he is "interested" in me), and that such mental state attributions to direct gaze may be reduced or absent in the autistic brain.

Reduced functional connectivity within and between 'social' resting state networks in autism spectrum conditions.

Individuals with autism spectrum conditions (ASC) have difficulties in social interaction and communication, which is reflected in hypoactivation of brain regions engaged in social processing, such as medial prefrontal cortex (mPFC), amygdala and insula. Resting state studies in ASC have identified reduced connectivity of the default mode network (DMN), which includes mPFC, suggesting that other resting state networks incorporating 'social' brain regions may also be abnormal. Using seed-based connectivity and group independent component analysis (ICA) approaches, we looked at resting functional connectivity in ASC between specific 'social' brain regions, as well as within and between whole networks incorporating these regions. We found reduced functional connectivity within the DMN in individuals with ASC, using both ICA and seed-based approaches. Two further networks identified by ICA, the salience network, incorporating the insula and a medial temporal lobe network, incorporating the amygdala, showed reduced inter-network connectivity. This was underlined by reduced seed-based connectivity between the insula and amygdala. The results demonstrate significantly reduced functional connectivity within and between resting state networks incorporating 'social' brain regions. This reduced connectivity may result in difficulties in communication and integration of information across these networks, which could contribute to the impaired processing of social signals in ASC.

Different neural mechanisms within occipitotemporal cortex underlie repetition suppression across same and different-size faces.

Repetition suppression (RS) (or functional magnetic resonance imaging adaptation) refers to the reduction in blood oxygen level-dependent signal following repeated presentation of a stimulus. RS is frequently used to investigate the role of face-selective regions in human visual cortex and is commonly thought to be a "localized" effect, reflecting fatigue of a neuronal population representing a given stimulus. In contrast, predictive coding theories characterize RS as a consequence of "top-down" changes in between-region modulation. Differentiating between these accounts is crucial for the correct interpretation of RS effects in the face-processing network. Here, dynamic causal modeling revealed that different mechanisms underlie different forms of RS to faces in occipitotemporal cortex. For both familiar and unfamiliar faces, repetition of identical face images (same size) was associated with changes in "forward" connectivity between the occipital face area (OFA) and the fusiform face area (FFA) (OFA-to-FFA). In contrast, RS across image size was characterized by altered "backward" connectivity (FFA-to-OFA). In addition, evidence was higher for models in which information projected directly into both OFA and FFA, challenging the role of OFA as the input stage of the face-processing network. These findings suggest "size-invariant" RS to faces is a consequence of interactions between regions rather than being a localized effect.

"You talkin' to me?" Self-relevant auditory signals influence perception of gaze direction.

In humans, direct gaze typically signals a deliberate attempt to communicate with an observer. An auditory signal with similar signal value is calling someone's name. We investigated whether the presence of this personally relevant signal in the auditory modality would influence perception of another individual's gaze. Participants viewed neutral faces displaying different gaze deviations while hearing someone call their own name or the name of another person. Results were consistent with our predictions, as participants judged faces with a wider range of gaze deviations as looking directly at them when they simultaneously heard their own name. The influence of this personally relevant signal was present only at ambiguous gaze deviations; thus, an overall response bias to categorize gaze as direct when hearing one's own name cannot account for the results. This study provides the first evidence that communicative intent signaled via the auditory modality influences the perception of another individual's gaze.

Inhibition of return to social signals of fear.

The present study examined whether inhibition of return (IOR) is modulated by the fear relevance of the cue. Experiment 1 found similar magnitude of IOR was produced by neutral and fear faces and luminance matched cues. To allow a more sensitive measure of endogenously directed attention, Experiment 2 removed a central reorienting cue and more precisely measured the time course of IOR. At stimulus onset asynchronies (SOAs) of 500, 1,000 and 1,500 ms, fear face and luminance matched cues resulted in similar IOR. These findings suggest that IOR is triggered by event onsets and disregards event value. Views of IOR as an adaptive "foraging facilitator," whereby attention is guided to promote optimal sampling of important environmental events, are discussed.