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Nutr Metab Cardiovasc Dis ; 28(8): 822-829, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29954641

RESUMO

BACKGROUND AND AIMS: Low vitamin D (vitD) has been linked to increased cardiovascular (CV) risk, but the effects of vitD supplementation are not clarified. We evaluated the impact of vitD normalization on HDL cholesterol efflux capacity (CEC), which inversely correlates with CV risk, the proatherogenic serum cholesterol loading capacity (CLC), adipokine profile and subclinical atherosclerosis. METHODS AND RESULTS: Healthy premenopausal women with vitD deficiency (n = 31) underwent supplementation. Subclinical atherosclerosis was evaluated by flow-mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AIx), measured with standard techniques. HDL CEC and serum CLC were measured by a radioisotopic and fluorimetric assay, respectively. Malondialdehyde (MDA) in HDL was quantified by the TBARS assay. Pre-ß HDL was assessed by 2D-electrophoresis. Serum adipokines were measured by ELISA. VitD replacement restored normal levels of serum 25-hydroxyvitamin D (25OHD) and significantly improved FMD (+4%; p < 0.001), PWV (-4.1%: p < 0.001) and AIx (-16.1%; p < 0.001). Total CEC was significantly improved (+19.5%; p = 0.003), with a specific increase in the ABCA1-mediated CEC (+70.8%; p < 0.001). HDL-MDA slightly but significantly decreased (-9.6%; p = 0.027), while no difference was detected in pre-ß HDL. No change was observed in aqueous diffusion nor in the ABCG1-mediated CEC. Serum CLC was significantly reduced (-13.3%; p = 0.026). Levels of adiponectin were increased (+50.6%; p < 0.0001) and resistin levels were decreased (-24.3%; p < 0.0001). After vitD replacement, an inverse relationship was found linking the ABCA1-mediated CEC with pre-ß HDL (r2 = 0.346; p < 0.001) and resistin (r2 = 0.220; p = 0.009). CONCLUSION: Our data support vitD supplementation for CV risk prevention.


Assuntos
Adipocinas/sangue , Aterosclerose/prevenção & controle , Colecalciferol/administração & dosagem , HDL-Colesterol/sangue , Suplementos Nutricionais , Lipoproteínas de Alta Densidade Pré-beta/sangue , Pré-Menopausa/sangue , Deficiência de Vitamina D/tratamento farmacológico , Transportador 1 de Cassete de Ligação de ATP/metabolismo , Adulto , Doenças Assintomáticas , Aterosclerose/sangue , Aterosclerose/diagnóstico , Aterosclerose/etiologia , Biomarcadores/sangue , Colecalciferol/efeitos adversos , Suplementos Nutricionais/efeitos adversos , Feminino , Humanos , Estudo de Prova de Conceito , Resistina/sangue , Fatores de Tempo , Resultado do Tratamento , Turquia , Vitamina D/análogos & derivados , Vitamina D/sangue , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/complicações , Deficiência de Vitamina D/diagnóstico
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