[Single nucleotide polymorphisms of the CYP11B2, GNB3 and NOS3 genes in various ethnic groups of arctic zone of yakutia suffering from arterial hypertension].

OBJECTIVE: Introduction: This article presents the results of a study of the frequencies of single nucleotide polymorphisms of the CYP11B2 -344 T> C genes; GNB3 825 C> T; NOS3 -786 T> C and 894 G> T in different ethnic groups of residents of the Arctic zone of the republic "Sakha" (Yakutia), suffering from essential arterial hypertension. The aim: The aim of this study is to determine the presence of statistically significant differences in the frequencies of the above-mentioned polymorphisms in the studied ethnic groups of people living in the Arctic zone of Yakutia. PATIENTS AND METHODS: Materials and methods: The material for the study was whole blood obtained during venipuncture. The volunteer groups studied were formed along ethnic lines and included the Yakuts, Slavs, Evens, and Evenks. Further, the representatives of the aforementioned ethnic groups were further grouped by aboriginal basis, in accordance with which the following groups were formed: "Indigenous Minorities of the Arctic Zone" and "Non-Indigenous Ethnic Groups of the Arctic Zone". To identify the polymorphisms indicated above, the method of real-time polymerase chain reaction with detection of the melting point of duplexes was used. RESULTS: Results: As a result, statistically significant (p ≤ 0.05) differences between the considered, in the framework of this study, ethnic groups at the points CYP11B2 -344 T> C; NOS3 -786 T> C and 894 G> T. CONCLUSION: Conclusions: The revealed differences can be further considered as a basis for studying the clinical features of the course of arterial hypertension in people with polymorphisms of the respective genes, as well as a basis for further pharmacogenetic studies.

The HELIO-geophysical storminess health effects in the cardio-vascular system of a human in the middle and high latitudes.

INTRODUCTION: cardiovascular impairment remains one of the most current problems of today's life and the definition of the connection between its development and the state of heliogeophysical storminess is currently important. The results of long-term researches of communication between cardiovascular catastrophes (myocardial infarction) and heliogeophysical storminess in the middle and high latitudes are shown in this work. AIM: to study the influence of space weather parameters on human cardio-vascular system in the high and middle latitudes. To define the particular space weather parameters and the mechanisms of their influence on human myocardial infarction progressing. MATERIAL AND METHODS: for the statistical processing of medical records data we use a spectral-time analysis, a correlation method and a method of overlapping of epochs. We have studied about 145 thousand medical records of ambulance medical services for the period of 1992 -2001. In order to define the reasons influencing the development of a myocardial infarction, we have made a comparison of myocardial infarction progress cases with Kp-index characterizing the level of geomagnetic storminess. RESULTS: the coincidence of geomagnetic storminess maximum with the cases of myocardial infarction, as well as the number of heart attacks excess in 1.5 times per a year near the maximum heliogeophysical activity (1992) compared to the year near the minimum of activity (1998) indicate possible influence of geomagnetic storminess on the myocardial infarction development of people living in subauroral latitudes. CONCLUSIONS: it was concluded that the appearance of heliogeophysical storminess in the myocardial infarction development in the mid-latitudes is largely due to the presence of Pc1 geomagnetic pulsations, and in the high latitudes, especially in maximum years of heliogeophysical storminess, it is due to the geomagnetic storminess caused by the parameters of the solar wind and the interplanetary magnetic field.

The HELIO-geophysical storminess health effects in the cardio-vascular system of a human in the middle and high latitudes.

INTRODUCTION: cardiovascular impairment remains one of the most current problems of today's life and the definition of the connection between its development and the state of heliogeophysical storminess is currently important. The results of long-term researches of communication between cardiovascular catastrophes (myocardial infarction) and heliogeophysical storminess in the middle and high latitudes are shown in this work. AIM: to study the influence of space weather parameters on human cardio-vascular system in the high and middle latitudes. To define the particular space weather parameters and the mechanisms of their influence on human myocardial infarction progressing. MATERIAL AND METHODS: for the statistical processing of medical records data we use a spectral-time analysis, a correlation method and a method of overlapping of epochs. We have studied about 145 thousand medical records of ambulance medical services for the period of 1992 -2001. In order to define the reasons influencing the development of a myocardial infarction, we have made a comparison of myocardial infarction progress cases with Kp-index characterizing the level of geomagnetic storminess. RESULTS: the coincidence of geomagnetic storminess maximum with the cases of myocardial infarction, as well as the number of heart attacks excess in 1.5 times per a year near the maximum heliogeophysical activity (1992) compared to the year near the minimum of activity (1998) indicate possible influence of geomagnetic storminess on the myocardial infarction development of people living in subauroral latitudes. CONCLUSIONS: it was concluded that the appearance of heliogeophysical storminess in the myocardial infarction development in the mid-latitudes is largely due to the presence of Pc1 geomagnetic pulsations, and in the high latitudes, especially in maximum years of heliogeophysical storminess, it is due to the geomagnetic storminess caused by the parameters of the solar wind and the interplanetary magnetic field.