RESUMO
Experiments on noninbred rats showed that the chronic intoxication with organophosphorus compounds sarin and methylparathion (30 days; total dose, 0.9 LD50; single daily dose, 0.03 mg/kg,) significantly decreases the immune responses and reduces the concentrations of blood cytokines IFN-gamma, IL-2, IL-4, IL-6, and IL-10. The damage is more pronounced in Th1 cells than in Th2 lymphocytes. The administration of imunofan (single daily dose, 20 microg/kg) for 5 days partly recovers the immune status and the content of cytokines in the blood.
Assuntos
Imunidade Inata/efeitos dos fármacos , Fatores Imunológicos/administração & dosagem , Metil Paration/toxicidade , Oligopeptídeos/administração & dosagem , Sarina/toxicidade , Células Th1/efeitos dos fármacos , Animais , Inibidores da Colinesterase/toxicidade , Feminino , Hipersensibilidade Tardia/imunologia , Fatores Imunológicos/uso terapêutico , Injeções Intramusculares , Injeções Subcutâneas , Interferon gama/sangue , Interleucina-10/sangue , Interleucina-2/sangue , Interleucina-4/sangue , Interleucina-6/sangue , Masculino , Oligopeptídeos/uso terapêutico , Ratos , Células Th1/citologia , Células Th1/imunologia , Células Th2/citologia , Células Th2/efeitos dos fármacos , Células Th2/imunologiaRESUMO
It has been established in experiments on non-inbred rats that the administration of cholinesterase reactivator carboxim in a single dose of 10 mg/kg signifucantly reduces the inactivation of acetylcholinesterase in T-lymphocytes caused by acute intoxication with organophosphorus compounds (sarin, metaphos) in a dose of 1.0 LD50. The drug administration leads to partial or almost complete recovery of the humoral and cellular immune responses. Carboxim does not influence the T-independent humoral immune response reduced due to suppression of B-cell (plasmocyte) function by organophosphorus compounds.