RESUMO
A case of a 3 1/2 year old female child is described in which symptomless cutaneous xanthomatosis led to the diagnosis of sitosterolaemia in the presence of a defect of low-density lipoprotein uptake by cultured fibroblasts. The condition responded to treatment by cholestyramine with normalisation of the blood lipid levels. Normal growth and development continued for three years of observation.
Assuntos
Heterozigoto , Hiperlipoproteinemia Tipo II/genética , Sitosteroides/sangue , Pré-Escolar , Feminino , Humanos , Hiperlipoproteinemia Tipo II/sangue , Hiperlipoproteinemia Tipo II/tratamento farmacológico , Lipoproteínas/sangueRESUMO
A clinical trial compared the relative efficacy of tetracycline hydrochloride 250 mg qid and minocycline hydrochloride 100 mg bid given for an initial period of ten days to 59 patients suffering from non-gonococcal urethritis (NGU). Those patients with persistent symptoms or signs on completion of the initial course were given a second course for a further ten days at the same dosage. The treatments were equivalent. A significant number of patients not clinically cured after one course of treatment responded satisfactorily to a second course.
Assuntos
Minociclina/uso terapêutico , Tetraciclina/uso terapêutico , Tetraciclinas/uso terapêutico , Uretrite/tratamento farmacológico , Adolescente , Adulto , Avaliação de Medicamentos , Humanos , Masculino , Nova Zelândia , Uretrite/diagnósticoRESUMO
Forty-six patients with herpes zoster were randomised into two groups treated with DMSO alone and 5 percent IDU in DMSO, provided that treatment started within 48 hours of the appearance of a rash. In the IDU group the interval before pain improved was significantly shorter than in the control DMSO group, and significantly fewer new vesicles developed at the three day follow up in the active group compared with the control group. These findings are in agreement with previously published work and confirm the usefulness of Zostrum (5 percent IDU in DMSO) in the treatment of herpes zoster.
Assuntos
Dimetil Sulfóxido/uso terapêutico , Herpes Zoster/tratamento farmacológico , Idoxuridina/uso terapêutico , Administração Tópica , Analgésicos/uso terapêutico , Ensaios Clínicos como Assunto , Dimetil Sulfóxido/efeitos adversos , Toxidermias/etiologia , Humanos , Idoxuridina/efeitos adversos , Dor/tratamento farmacológico , Distribuição AleatóriaRESUMO
Ten patients presenting with venereal or dermatological disorders have been found to have evidence of infection with the virus of hepatitis B; only five had distinguishable liver dysfunction, yet all had either detectable antigen or antibody. Antigen subtype ayw has been identified in four of these people. Once rare in the local population, hepatitis B virus infection appears to be increasing in incidence with cases attributable to inoculation and to direct contact, as well as presenting as a covert partner to gonorrhoea, urethritis and candidiasis. Testing for hepatitis B antigen and antibody is recommended for patients attending the venereal diseases clinic, for patients presenting for removal of tattoos, for those with suspected drug taking and for Polynesians, in whom the carrier rate may be expected to be high (Austin and others, 1974). In our current clinical practice the sterilisation of instruments, the handling of patients, and the transmission of specimens to the laboratory have been reviewed in the light of the US Public Health Service supplement 1976, Perspectives on the Control of Viral Hepatitis, Type B.
