[Effectiveness of hemofiltration in patients with peritonitis and acute respiratory distress syndrome].

The subjects of the study were 149 patients with severe pyo-septic complications of abdominal diseases, resulting in multiple organ failure syndrome (MOFS) with clinical and laboratory manifestations. Acute respiratory distress syndrome (ARDS) as a component of MOFS was diagnosed in 39 (26.2%) patients. The complex treatment included hemofiltration in a volume of at least 25 liters. The study shows that hemofiltration is an effective and pathogenetic method of complex treatment of MOFS, which has a positive effect on the main pathogenetic mechanisms in ARDS, thus allowing improvement of oxygen transport in blood. Hemofiltration improves central hemodynamics as well as blood circulation in the lungs and peripheral tissues in patients with MOFS and ARDS; it allows correction of volemic and metabolic disorders, and endogenous intoxication reduction. The use of hemofiltration in ARDS led to a 2-fold lethality reduction.

[Continuous low-flow vein-vein hemofiltration in peritonitis: changes in the severity of endotoxicosis as a criterion for the efficiency of the technique].

The efficiency of intermittent and continuous hemofiltration was comparatively evaluated in the complex treatment of 27 patients having multiple organ dysfunction along with pyoseptic complications of abdominal diseases. Based on the study of a broad spectrum of markers of toxicosis and the severity of organ dysfunction, it was concluded that the efficiency of the procedure should be objectively evaluated to optimize the time of its performance.