RESUMO
Rats (SHR) weighing 240 +/- 10 g with spontaneous hypertension were given intraperitoneally porcine prolactin in doses from 0.2 to 2000 micrograms/kg of body weight. The systolic pressure was measured before hormone administration and 2 hours after it. It was found that prolactin in doses of 200 to 2000 micrograms/kg caused a decrease of the systolic pressure by 22%. The dose of 20 micrograms/kg decreased this pressure by 9% and the dose of 0.2 microgram/kg by 7.9%.
Assuntos
Hipertensão/fisiopatologia , Hipotensão/induzido quimicamente , Prolactina/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Masculino , Ratos , Ratos Endogâmicos SHRRESUMO
Fifty malignant melanomas of the skin were aspirated with a fine needle, and the cytomorphologic features of the smears were evaluated. An attempt was made to establish the frequency of morphologic features found in melanoma cells. The following features were regarded as frequent: lack of cohesiveness between the malignant cells; binucleated, multinucleated and giant cells; and intranuclear "vacuoles." The nuclei usually had a regular outline, and the nuclear chromatin was evenly distributed. The majority of the smears contained a mixture of epithelial-type and spindle cells. The nuclei of the epithelial-type cells were usually in an eccentric position. The morphologic features of malignant cells in smears, as described, can be helpful in making the preoperative cytologic diagnosis of nonpigmented malignant melanoma of the skin.
