Increased all-cause, liver, and cardiac mortality among hepatitis C virus-seropositive blood donors.

Hospital-based studies suggest that hepatitis C virus (HCV) infection causes frequent cirrhosis, hepatocellular carcinoma, and mortality, but epidemiologic studies have shown less morbidity and mortality. The authors performed a retrospective cohort study of 10,259 recombinant immunoblot assay-confirmed, HCV antibody-positive (HCV+), allogeneic blood donors from 1991 to 2002 and 10,259 HCV antibody-negative (HCV-) donors matched for year of donation, age, gender, and Zone Improvement Plan Code (ZIP Code). Vital status through 2003 was obtained from the US National Death Index, and hazard ratios with 95% confidence intervals were calculated by survival analysis. After a mean follow-up of 7.7 years, there were 601 (2.92%) deaths: 453 HCV+ and 148 HCV- (hazard ratio (HR) = 3.13, 95% confidence interval (CI): 2.60, 3.76). Excess mortality in the HCV+ group was greatest in liver-related (HR = 45.99, 95% CI: 11.32, 186.74), drug- or alcohol-related (HR = 10.81, 95% CI: 4.68, 24.96), and trauma/suicide (HR = 2.99, 95% CI: 2.05, 4.36) causes. There was also an unexpected increase in cardiovascular mortality among the HCV+ donors (HR = 2.21, 95% CI: 1.41, 3.46). HCV infection is associated with a significant, threefold increase in overall mortality among former blood donors, including significantly increased mortality from liver and cardiovascular causes. High rates of mortality from drug/alcohol and trauma/suicide causes are likely due to lifestyle factors and may be at least partially preventable.

Safety and donor acceptance of an abbreviated donor history questionnaire.

BACKGROUND: Surveys have shown donor dissatisfaction with the duration of the donation process and repetitive questioning. An abbreviated donor history questionnaire (AQ) may improve satisfaction, but must be safe. STUDY DESIGN AND METHODS: An FDA-approved 34-question AQ was implemented in 2003. Travel, medication, and health history questions were decreased by 18. Donors were eligible for AQ if they had successfully completed three donor suitability assessments on the full-length questionnaire (FQ), including one in the prior 6 months. Data were analyzed from more than 50,000 donations during each of three 20-day periods over the first year of progressive implementation of the AQ. We evaluated the performance of the AQ by comparing donor deferrals for medical history (MHD), physical examination findings (PED), and reactive screening and/or confirmatory tests (RSCT) for viral markers among AQ-ineligible and AQ-eligible donors and separately among AQ-eligible donors who received AQ or FQ. RESULTS: Approximately one-third of presenting donors were AQ-eligible. Use of AQ progressed from 48 percent in October 2003 to 76 percent in November 2004. AQ-eligible donors had lower rates of MHD, PED, and RSCT than donors ineligible for AQ (p < 0.05). Among donors eligible for the AQ, those who received the FQ had slightly more MHD and PED than those who received the AQ (p < 0.05), but there was no difference in RSCT. A postdonation survey indicated significantly increased satisfaction and intent to donate among donors who received the AQ. CONCLUSIONS: In frequent repeat donors, use of an AQ led to increased donor satisfaction and no significant medical concerns about donor or recipient safety.