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4.
Surv Ophthalmol ; 67(4): 1160-1174, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34813853

RESUMO

Oculomotor nerve schwannomas are rare benign cranial nerve tumors. There are only a limited number of reports on this pathology in the literature, and there are currently no established management guidelines that aid providers in deciding on surgical versus nonsurgical management. We assess the published literature on the topic to identify indications for treatment as well as outcome measures (e.g., local control rates, survival rates, and complication rates) that have been reported as associated with the various treatment modalities. We attempt to develop an algorithm for evaluation and treatment of oculomotor nerve schwannomas in order to establish consensus on how these tumors should be treated.


Assuntos
Neoplasias dos Nervos Cranianos , Neurilemoma , Doenças do Nervo Oculomotor , Algoritmos , Neoplasias dos Nervos Cranianos/complicações , Neoplasias dos Nervos Cranianos/diagnóstico , Neoplasias dos Nervos Cranianos/cirurgia , Humanos , Neurilemoma/complicações , Neurilemoma/diagnóstico , Neurilemoma/cirurgia , Nervo Oculomotor/patologia , Doenças do Nervo Oculomotor/diagnóstico , Doenças do Nervo Oculomotor/etiologia
12.
Ophthalmic Genet ; 35(2): 117-8, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23647425

RESUMO

PURPOSE: To report optic disc dysplasia in a case of Poland syndrome. DESIGN: Non-interventional case report. METHODS: A 2-year-old boy with Poland syndrome was referred for ophthalmic evaluation after abnormal optic discs were found on exam. RESULTS: Physical exam at birth revealed right-sided aplasia of the pectoralis major muscle, symbrachydactyly, hypoplastic scapula, and an abnormal third rib. On dilated examination the optic nerve heads were dysplastic. The findings included multiple cilioretinal vessels, situs inversus, inferotemporal excavation, and surrounding pigmentary disturbances. CONCLUSION: Only one case of optic disc anomaly has been reported in Poland syndrome and was described as morning glory syndrome. The optic discs in our patient do not fit well with other optic disc excavation syndromes but are most reminiscent of those in papillorenal syndrome. As both Poland syndrome and papillorenal syndrome share vascular dysfunction as a possible etiology, this case adds to the literature of vascular dysgenesis in Poland syndrome.


Assuntos
Anormalidades do Olho/etiologia , Disco Óptico/anormalidades , Síndrome de Poland/complicações , Pré-Escolar , Artérias Ciliares/patologia , Anormalidades do Olho/diagnóstico , Humanos , Masculino , Disco Óptico/irrigação sanguínea , Síndrome de Poland/diagnóstico , Vasos Retinianos/patologia
14.
Retin Cases Brief Rep ; 7(2): 146-9, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-25390808

RESUMO

PURPOSE: The purpose of this study was to report a case series of patients with acute macular neuroretinopathy in which patients concomitantly used oral norepinephrine reuptake inhibitors. METHODS: Retrospective case review. PATIENTS: Three patients with retinal findings consistent with acute macular neuroretinopathy are presented. CONCLUSION: The use of oral neuromodulators should be considered in cases of acute macular neuroretinopathy.

17.
J Neuroophthalmol ; 31(2): 117-20, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21343829

RESUMO

BACKGROUND: Unilateral Duane retraction syndrome type 1 (DRS-I) and unilateral sixth nerve palsy (6NP) present with limitation of abduction, incomitant esotropia, and frequently, a compensatory head turn. The purpose of this study was to compare the mean primary position measurement and to correlate this with the abduction deficit to determine if these measurements may be used to differentiate between the 2 conditions when other clinical signs of DRS-I (globe retraction, changes in lid fissure height, and upshoots/downshoots) are subtle. METHODS: A database search of patients examined over a 5-year period revealed 69 cases of DRS-I and 62 cases of unilateral 6NP. Primary position measurements both at distance and near and limitation of abduction on version testing were recorded and compared. RESULTS: Mean abduction deficit was -3.5 ± 0.1 for DRS-I and -2.6 ± 0.2 for 6NP (P = 0.0004). Mean esotropia at near was 8.4 ± 1.1 prism diopters (PD) for DRS-I and 27.2 ± 2.4 PD for 6NP (P < 0.0001). Mean esotropia at distance was 10.3 ± 1.3 PD for DRS-I and 36.4 ± 2.4 PD for 6NP (P < 0.0001). The mean distance-near disparity for DRS-I was 1.94 ± 0.62 PD and 9.19 ± 1.28 PD for 6NP (P < 0.0001). The age-group of ≤2 years consisted of 23 DRS-I and only 2 6NP cases. The age-group between >2 years and <18 years had 41 DRS-I and 16 6NP cases, respectively. Finally, the age-group of ≥18 years had only 5 DRS-I and 44 6NP cases (P < 0.0001). CONCLUSION: Patients with DRS-I showed greater abduction deficit yet significantly less esotropia in primary position than those with 6NP. Patients with 6NP were more likely to have a significant distance-near disparity. In addition, patients with DRS-I tended to be younger than those with 6NP. This report documents that DRS-I and 6NP can be differentiated based on magnitude of primary position esotropia, comparison of primary position esotropia with severity of abduction deficit, distance-near disparity, and patient age.


Assuntos
Doenças do Nervo Abducente/patologia , Nervo Abducente/fisiopatologia , Síndrome da Retração Ocular/patologia , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Lateralidade Funcional , Humanos , Lactente , Modelos Logísticos , Masculino , Músculos Oculomotores/patologia , Músculos Oculomotores/fisiopatologia , Estudos Retrospectivos , Adulto Jovem
19.
Ultrastruct Pathol ; 34(2): 78-81, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-20192704

RESUMO

Mitochondrial diseases are a large group of disorders resulting from mutations of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA). Patients present clinically with multiple manifestations, including myopathies and multiple system disorders. Establishing a specific diagnosis often requires extensive clinical and laboratory evaluation. In this study of 2 adult patients with presumptive mitochondrial disease, the authors have identified distinctive morphological changes in medial rectus muscle biopsies that confirm the diagnosis of chronic progressive external ophthalmoplegia (CPEO). These findings demonstrate the usefulness of electron microscopy using medial rectus muscle in the diagnosis of adult patients with a slowly progressive course of mild skeletal weakness and CPEO.


Assuntos
DNA Mitocondrial/genética , Fibras Musculares Esqueléticas/ultraestrutura , Mutação , Músculos Oculomotores/ultraestrutura , Oftalmoplegia Externa Progressiva Crônica/diagnóstico , Idoso , DNA Mitocondrial/sangue , Feminino , Humanos , Microscopia Eletrônica de Transmissão/métodos , Pessoa de Meia-Idade , Tamanho Mitocondrial , Oftalmoplegia Externa Progressiva Crônica/genética
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