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1.
J Behav Med ; 47(3): 355-373, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38017250

RESUMO

Studies show that interpersonal relations impact behavior change. Yet, a comprehensive review of their efficacy remains unclear. This systematic review examines the efficacy of dyadic and group-based studies that intervened on primary endpoints: diet, PA, and weight loss in adults and their networks. We searched five databases for eligible articles published from 1980 to present. Final inclusion and risk of bias were independently determined and agreed upon by two of the paper's co-authors. Nine dyads and twelve group-based studies were eligible. Of the studies, 36% (4/11) of PA studies, 60% (3/5) of diet studies and 57% (8/14) of studies with weight loss as primary outcomes, reported significant findings. Compared to dyadic interventions, a greater proportion of group-based interventions demonstrated efficacy in PA gain and weight loss as outcomes. Approximately 43% of studies demonstrated low to moderate methodological quality. This systematic review synthesized the evidence of dyadic and group studies that intervened on PA, diet, and weight in adults from the same network. Moderately-high risk of bias and lack of diverse representation restricts inferences around efficacy. High-quality rigorous research is needed to understand the efficacy of dyadic and group-based interventions in addressing these co-occurring endpoints of interest.


Assuntos
Dieta , Redução de Peso , Adulto , Humanos , Exercício Físico , Relações Interpessoais
2.
J Immigr Minor Health ; 23(5): 1011-1020, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33043411

RESUMO

African American and Hispanic women report less physical activity (PA) than non-Hispanic White women. As such, a digitally-enhanced 16-week social support pilot intervention was conducted to promote PA among African American and Hispanic women dyads. This study quantitatively and qualitatively examined the engagement and satisfaction of participants (N = 30; 15 dyads) assigned to the intervention. Intervention participants received telephone counseling calls based on motivational interviewing and a Jawbone UP activity monitor. Intervention engagement and satisfaction data were collected from the Jawbone UP, call logs, self-report questionnaires conducted at the 16-week follow-up, and two post-intervention focus groups. Nonparametric tests assessed group differences across engagement and satisfaction measures, and a manually-driven coding scheme was used to evaluate emerging themes from qualitative text. Participants demonstrated high engagement in the telephone counseling sessions and moderate engagement with the Jawbone UP. Friend/co-worker dyads and participants who were 45 years and older were more likely to use the device. Qualitative results emphasized participants' appreciation for the counseling calls, the Jawbone UP, and the overall dyadic framework of the study to collectively nurture social support and accountability for PA. Overall, the intervention group reacted positively to study components. Additional research is needed to understand the role of technology in facilitating long-lasting PA change via social support in minority populations.


Assuntos
Negro ou Afro-Americano , Satisfação Pessoal , Exercício Físico , Feminino , Humanos , Projetos Piloto , Apoio Social
3.
J Subst Abuse ; 13(3): 337-46, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11693456

RESUMO

PURPOSE: To examine heroin use and associated morbidity in young adults undergoing drug detoxification. METHODS: A retrospective chart review of all persons (ages 18-25) admitted to either of the two state-funded detoxification facilities in Rhode Island was conducted between June 1998 and June 1999. Only those reporting heroin as a primary drug were included in this study (N=201). RESULTS: Clients were largely male (64%), and white (79%), with a mean age of 22. Of those that reported heroin as their primary drug, 62% used primarily by injection. Mean age of initiation for heroin use was 18.3 years. Twenty-two percent reported a psychiatric diagnosis, and 80% reported a substance-abusing family member. Injection, previous overdose, and a mother with a history of substance use were associated with early initiation of heroin use. CONCLUSIONS: The majority of young adults with heroin addiction undergoing detoxification began using heroin during late adolescence. Concurrence of psychiatric and medical diagnoses with heroin addiction was common, and may contribute to the severity of drug use. Efforts to identify risk factors for heroin and other injection drug use in adolescents and young adults will be critical for the design of effective interventions to prevent injection drug use and its associated morbidities.


Assuntos
Comportamento do Adolescente/psicologia , Comportamento Aditivo/psicologia , Dependência de Heroína/psicologia , Adolescente , Adulto , Comportamento Aditivo/epidemiologia , Saúde da Família , Feminino , Dependência de Heroína/epidemiologia , Humanos , Masculino , Transtornos Mentais/psicologia , Estudos Retrospectivos , Rhode Island/epidemiologia , Centros de Tratamento de Abuso de Substâncias
4.
AIDS Read ; 10(7): 421-9, 2000 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10932846

RESUMO

In the United States today, half of all new HIV infections are injection drug use-associated, many of which are a result of the reuse and sharing of contaminated syringes. Thus, providing access to sterile syringes for injection drug users is an important part of preventing HIV transmission. Needle exchange programs (NEPs) have been established as one successful approach to providing sterile injection equipment. The medical literature shows that these programs are effective in decreasing both syringe sharing and HIV incidence in injection drug users. In addition, many NEPs are also beneficial because they provide other injection drug use-relevant services. There are several strategies that can be adopted in order to optimize the impact of needle exchange programs, at both the community and national levels. These include establishing NEPs in communities that need them, expanding and improving those that already exist, and implementing such programs on a larger national scale with the provision of federal funds.


Assuntos
Síndrome da Imunodeficiência Adquirida/prevenção & controle , Programas de Troca de Agulhas , Abuso de Substâncias por Via Intravenosa/complicações , Síndrome da Imunodeficiência Adquirida/transmissão , Humanos
5.
J Neurosci ; 20(2): 649-59, 2000 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-10632594

RESUMO

The Drosophila trp gene encodes a light-activated Ca(2+) channel subunit, which is a prototypical member of a novel class of channel proteins. Previously identified trp mutants are all recessive, loss-of-function mutants characterized by a transient receptor potential and the total or near-total loss of functional TRP protein. Although retinal degeneration does occur in these mutants, it is relatively mild and slow in onset. We report herein a new mutant, Trp(P365), that does not display the transient receptor potential phenotype and is characterized by a substantial level of the TRP protein and rapid, semi-dominant degeneration of photoreceptors. We show that, in spite of its unusual phenotypes, Trp(P365) is a trp allele because a Trp(P365) transgene induces the mutant phenotype in a wild-type background, and a wild-type trp transgene in a Trp(P365) background suppresses the mutant phenotype. Moreover, amino acid alterations that could cause the Trp(P365) phenotype are found in the transmembrane segment region of the mutant channel protein. Whole-cell recordings clarified the mechanism underlying the retinal degeneration by showing that the TRP channels of Trp(P365) are constitutively active. Although several genes, when mutated, have been shown to cause retinal degeneration in Drosophila, the underlying mechanism has not been identified for any of them. The present studies provide evidence for a specific mechanism for massive degeneration of photoreceptors in Drosophila. Insofar as some human homologs of TRP are highly expressed in the brain, a similar mechanism could be a major contributor to degenerative disorders of the brain.


Assuntos
Substituição de Aminoácidos , Canais de Cálcio/genética , Mapeamento Cromossômico , Drosophila melanogaster/genética , Células Fotorreceptoras de Invertebrados/citologia , Células Fotorreceptoras de Invertebrados/fisiologia , Mutação Puntual , Sequência de Aminoácidos , Animais , Canais de Cálcio/química , Canais de Cálcio/metabolismo , Drosophila melanogaster/fisiologia , Eletrorretinografia , Genes de Insetos , Humanos , Microscopia Confocal , Dados de Sequência Molecular , Degeneração Neural/genética , Fenótipo , Retina/ultraestrutura , Canais de Cátion TRPC
6.
Proc Natl Acad Sci U S A ; 96(23): 13474-9, 1999 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-10557345

RESUMO

The trp gene of Drosophila encodes a subunit of a class of Ca(2+)-selective light-activated channels that carry the bulk of the phototransduction current. Transient receptor potential (TRP) homologs have been identified throughout animal phylogeny. In vertebrates, TRP-related channels have been suggested to mediate "store-operated Ca(2+) entry," which is important in Ca(2+) homeostasis in a wide variety of cell types. However, the mechanisms of activation and regulation of the TRP channel are not known. Here, we report on the Drosophila inaF gene, which encodes a highly eye-enriched protein, INAF, that appears to be required for TRP channel function. A null mutation in this gene significantly reduces the amount of the TRP protein and, in addition, specifically affects the TRP channel function so as to nearly shut down its activity. The inaF mutation also dramatically suppresses the severe degeneration caused by a constitutively active mutation in the trp gene. Although the reduction in the amount of the TRP protein may contribute to these phenotypes, several lines of evidence support the view that inaF mutations also more directly affect the TRP channel function, suggesting that the INAF protein may have a regulatory role in the channel function.


Assuntos
Canais de Cálcio/fisiologia , Proteínas de Drosophila , Proteínas do Olho/fisiologia , Proteínas de Insetos/fisiologia , Proteínas Adaptadoras de Transdução de Sinal , Animais , Western Blotting , Proteínas do Olho/genética , Microscopia de Fluorescência , Dados de Sequência Molecular , Mutação , Células Fotorreceptoras de Invertebrados/fisiologia , Canais de Potencial de Receptor Transitório
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