RESUMO
A 47-year-old patient without underlying disease was first treated for nocardial pneumonia in 1970. She has had three relapses of nocardial pneumonia despite treatment with sulfasoxazole and tetracycline for nine, 15, and 12 months for the first three episodes. Therapy was continued two, 12, and nine months after chest roentgenograms returned to normal. The recurrences occurred two, 39, and 11 months after therapy was discontinued.
Assuntos
Nocardiose/tratamento farmacológico , Pneumonia/tratamento farmacológico , Feminino , Humanos , Pessoa de Meia-Idade , Nocardiose/diagnóstico por imagem , Nocardia asteroides , Oxitetraciclina/uso terapêutico , Pneumonia/diagnóstico por imagem , Radiografia , Recidiva , Sulfonamidas/uso terapêuticoAssuntos
Síndrome de Secreção Inadequada de HAD/fisiopatologia , Vasopressinas/fisiologia , Demeclociclina/uso terapêutico , Humanos , Hipotireoidismo/complicações , Síndrome de Secreção Inadequada de HAD/tratamento farmacológico , Síndrome de Secreção Inadequada de HAD/etiologia , Lítio/uso terapêutico , Neoplasias/complicações , Concentração Osmolar , Vasopressinas/sangueAssuntos
Ácidos Graxos/biossíntese , Glicólise , Hormônios/fisiologia , Fígado/metabolismo , Acetil-CoA Carboxilase/metabolismo , Aerobiose , Animais , Bucladesina/farmacologia , Citratos/metabolismo , Ácido Graxo Sintases/metabolismo , Glucagon/farmacologia , Fígado/efeitos dos fármacos , Mitocôndrias Hepáticas/metabolismo , Complexo Piruvato Desidrogenase/metabolismo , Piruvato Quinase/metabolismoRESUMO
The pharmacokinetics of netilmicin were examined in 25 adult subjects, 7 normal subjects, and 18 patients with renal impairment. Five were dialysis patients who were studied on and off dialysis. Netilmicin, 2 mg/kg, was infused intravenously over 1 h. The peak serum concentration ranged from 9 to 11 mug/ml. The mean biological half-life of netilmicin for subjects with a creatinine clearance (Ccr) > 70 ml/min was 2.7 h, for those with Ccr > 25 < 70 ml/min it was 10 h, for those with Ccr > 4 < 25 ml/min it was 32 h, and for those who were anephric it was 42 h. Ccr was correlated positively with the elimination constant and the drug's serum clearance. It was negatively correlated with the drug's volume of distribution. The dialyzer clearance of netilmicin was positively correlated with plasma flow rate and was similar to values previously reported for gentamicin. Netilmicin behaves in a fashion similar to other aminoglycosides. Therapeutic guidelines are suggested.
