[Analysis of security by vitamin D of the elderly people.]

The purpose of the study was to analyze the frequency of detection of vitamin D deficiency in elderly people, identify clinically significant diseases, accompanied by a deficiency of vitamin 25(OH)D. A retrospective cohort study was conducted in 506 patients over 65 years of age (74,1±6,5 years). Patients were divided into three age groups: group A 65-74 years, group B 75-84 years, group C 85 years and older. The study of blood samples was carried out from September to May. The level of vitamin 25(OH)D was determined by the method of chemiluminescent immunoassay on the Abbott Architect 8000 analyzer (USA). Evaluation of vitamin 25(OH)D was performed according to the clinical recommendations of the Russian Endocrinology Association and the recommendations of the Russian Association for Osteoporosis. Among people older than 65 years, the average level of 25(OH)D was 20,9 ng/ml (range 2,3 to 70,5 ng/ml), 50% had vitamin D deficiency. With age, the proportion of patients with vitamin D deficiency increased more in the male population. Low values of vitamin 25(OH)D were more frequent in the spring. Arterial hypertension, obesity of varying degrees, sarcopenia increased the risk of vitamin D deficiency in 1,15-1,17-1,2 (р<0,05-0,01) times, respectively. Oncological diseases in the anamnesis were accompanied by low parameters of vitamin 25(OH)D in blood serum (p=0,084).

[Chronic gastritis in children with concomitant diseases of the thyroid gland]. / Khronicheskii gastrit u detei s sopustvuiushchimi zabolevaniiami shchitovidnoi zhelezy.

We examined: 1 group--16 children with chronic gastritis (CG) and autoimmune thyroiditis (AT); 2 group--41 children with functional thyroidal pathologies; 3 group--23 children with CG only. The average age in all groups was 11.17 +/- 2.98. HP (68%) was revealed equally frequently in all the groups. Antibodies to H+/K(+)-ATPase of parietal cells were revealed in the first and second groups only (31-36%), p < 0.05 as compared to the third group. CG of the stomach body was more frequently revealed in the first group using endoscopic and histological tests. The second group had more frequent and more apparent lesions of the antral part. Thus, in case of concomitant diseases of the thyroid gland CG has an autoimmune nature of an inflammation of the mucous coat of the stomach.

[The laboratory diagnosis of autoimmune thyroid diseases in those who worked in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station]. / Laboratornaia diagnostika autoimmunnykh zabolevanii shchitovidnoi zhelezy u likvidatorov posledstvii avarii na Chernobyl'skoi AES.

Serum antibodies to thyroid tissue antigens were tested by enzyme immunoassay and the thyroid hormonal status was analyzed in 80 liquidators of the Chernobyl accident consequences. Antibodies to thyroglobulin in concentration of 160.7 +/- 10.5 IU/ml were detected in 11 (13.7%) subjects 11-12 years after the accident. Antibodies to thyroperoxidase were detected in this cohort: the reaction was positive in 2.5% cases and weakly positive in 5%. Groups of liquidators with changed thyroid functional activity in the T3-T4-TTH system were identified. Immunochemical screening for thyroid hormones and antibodies is an affective method for the diagnosis of autoimmune thyroid diseases in liquidators.

[The relation of a number of hormonal indices to risk factors for IHD and its prevalence based on the data from a large population study]. / Sviaz' riada gormonal'nykh pokazatelei s faktorami riska IBS i ee rasprostranennost'iu po dannym krupnogo populiatsionnogo issledovaniia.

Relevance of IHD risk factors and hormone concentrations (insulin, estradiol, testosterone, prolactin, LH, FSH, TTH and hydrocortisone) to IHD incidence was studied in 1200 men. Multivariate statistical analysis demonstrated that only a small number of hormonal indices are associated with main lipid and nonlipid risk factors. The relationships exist between systolic arterial pressure (SAP) and hydrocortisone, between TTH and total cholesterol, SAP and age, estradiol, testosterone and age. Significant independent associations were found between IHD prevalence and age (R = 0.140, 3 = 0.000), SAP (R = 0.130, P.0.001), HDLP cholesterol (R = -0.082, P = 0.007), height (R = -0.078, P = 0.010), insulin (R = 0.067, P = 0.035), standard deviation of estradiol from median value (R = 0.083, P = 0.017). The findings confirm a great role of high SAP in the development of IHD, a significant and independent association of high insulin levels with IHD prevalence, the presence of nonlinear relation of estradiol concentration to IHD occurrence in males.

[Association of papillomavirus infection and latent hyperprolactinemia in patients with dysplasia and preinvasive cancer of the cervix uteri]. / Sochetanie papillomavirusnoi infektsii i skrytoi giperprolaktinemii u bol'nykh displaziei i preinvazivnym rakom sheiki matki.

Gynecological screenings carried out in I, 247 females and supplemented by cytological examination of ectoendocervical mucosa smears established significantly higher rates of detection of cytological signs of papillomavirus infection (PVI), regardless of age, in cases of background pathologies of the uterine cervix (10.0%) than in females without detectable pathology of the ectocervix (3.6%). Females of reproductive age revealed a significantly higher frequency of PVI-associated dysplasia and preinvasive carcinoma (4.2%) than in pre- and postmenopausal women (2.8%). In 24 patients with a combination of dysplasia, cervical flat condylomas and PVI signs, thyroliberin load served to identify higher levels of latent prolactin production as compared to healthy controls, the basal concentrations of blood prolactin being identical. Electrosurgical conization of the cervix was performed in 98 cases of cervical dysplasia. Morphological examination of resected tissue confirmed the relationship between PVI infection and degree of dysplasia in cervical epithelium.

[Multifactorial analysis of the effect of metabolic and endocrine factors on cellular immunity in patients with cancer of the uterine body]. / Mnogofaktornyi analiz vliianiia metabolicheskikh i éndokrinnykh faktorov na kletochnyi immunitet u bol'nykh rakom tela matki.

Multifactorial analysis of effects of metabolic and endocrine determinants of the host and morphology of the tumor on cellular immunity has been undertaken in 29 patients with cancer of the corpus uteri. Several regression models obtained using the Hocking-Leslie method demonstrated significant effects of age, obesity, triglyceride levels, morphologic differentiation of the tumor and magnitude of invasion on various levels of cellular immunity, presenting as an increase in T-helper and decrease in suppressor counts. The multifactorial analysis depicted additive effects of endocrine homeostatic determinants and the tumor on different aspects of cellular immunity in cancer of the corpus uteri.

[Hyperprolactinemia as a marker of the progression of cervical cancer]. / Giperprolaktinemiia kak marker progressii raka sheiki matki.

Elevated blood prolactin level was identified in 80% of untreated patients with advanced (stage II-IV) cervical cancer whereas it was normal at the earlier (preinvasive) stage. Patients with stage I-A, II tumors revealed either increased or normal blood prolactin level. Patients with advanced cancer who had undergone irradiation and surgery, either alone or in combination, showed hyperprolactinemia as often as 94% of the time. Studies on pathogenesis of hyperprolactinemia and its role in tumor progression are currently conducted by the authors.