Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Mech Ageing Dev ; 131(4): 242-52, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-20219522

RESUMO

Mitochondrial redox metabolism has long been considered to play important roles in mammalian aging and the development of age-related pathologies in the major oxidative organs. Both genetic and dietary manipulations of mitochondrial redox metabolism have been associated with the extension of lifespan. Here we provide a broad overview of the circumstantial evidence showing associations between mitochondrial reactive oxygen species (ROS) metabolism, aging and longevity. We address most aspects of mitochondrial ROS metabolism, from superoxide production, to ROS detoxification and the repair/removal of ROS-mediated macromolecular damage. Finally, we discuss the effects of dietary manipulations (e.g. caloric restriction, methionine restriction), dietary deficiencies (e.g. folate) and dietary supplementation (e.g. resveratrol) on mitochondrial ROS metabolism and lifespan.


Assuntos
Envelhecimento/metabolismo , Metionina/metabolismo , Metionina/farmacologia , Mitocôndrias/metabolismo , Envelhecimento/efeitos dos fármacos , Envelhecimento/genética , Animais , Restrição Calórica , Dieta , Suplementos Nutricionais , Longevidade/efeitos dos fármacos , Longevidade/genética , Metionina/genética , Mitocôndrias/genética , Oxirredução , Ratos , Espécies Reativas de Oxigênio/metabolismo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...