RESUMO
Isoflurane, hailed as the anesthetic of the 1980s, is less hepatotoxic than its predecessors, halothane and enflurane. Since its release by the Food and Drug Administration in 1979, controversy has existed about the extent to which isoflurane is capable of producing hepatotoxic effects. In this report, we provide direct evidence that isoflurane can induce liver injury and should therefore be considered as a potential cause of serum transaminase elevations in any patient who is exposed to this anesthetic.
Assuntos
Anestésicos Inalatórios/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Isoflurano/efeitos adversos , Idoso , Alanina Transaminase/sangue , Aspartato Aminotransferases/sangue , Biópsia , Doença Hepática Induzida por Substâncias e Drogas/diagnóstico , Doença Hepática Induzida por Substâncias e Drogas/epidemiologia , Humanos , Fígado/efeitos dos fármacos , Fígado/patologia , Masculino , Microscopia EletrônicaRESUMO
In order to determine the concurrent and predictive validity of the Pictorial Test of Intelligence for use with cerebral-palsied children, this test was administered to 46 cerebral-palsied children aged between four and seven years, together with the Columbia Mental Maturity Scale and Peabody Picture Vocabulary Test. The results, compared with a classroom Achievement Rating Scale, showed the Pictorial Test of Intelligence to be superior to the other two tests as a predictor of classroom achievement of the children in this study.
