Fabrication of a 2D metal-organic framework (MOF) nanosheet colloidal system and investigation of its fluorescence response to pesticide molecules.

Pesticides, as a type of toxic chemicals widely used for a long time, not only pollute the environment but also affect people's health and cause serious harm to the human body, soil and environment. Therefore, it is very necessary to exploit a portable and environmentally friendly method to detect pesticides with high sensitivity. Herein, a new luminescent metal-organic framework ([Zn(TPYBDC)·H2O]n, TPYBDC2- = 4'-(pyridin-4-yl)-[2,2':6',2''-terpyridine]-4,4''-dicarboxylate) with 2D coordination layers has been designed and assembled using 4'-(pyridin-4-yl)-[2,2':6',2''-terpyridine]-4,4''-dicarboxylic acid as the ligand. The as-synthesized Zn-LMOF was exfoliated to ultrathin 2D nanosheets (4-5 nm) to form a luminescence colloidal sensor by destroying the weak interaction between the coordination layers such as H-bonding between the matrix H2O and the coordination carboxyl oxygen, and the π-π interactions among the interlayer conjugated aromatic rings. Investigation of its recognition and detection ability towards chemical pesticides shows that it can sensitively detect pesticides such as imidacloprid, nitenpyram and dinotefuran via fluorescence quenching effect with very low detection limit (LOD). Using imidacloprid as a typical case, a LOD value of 0.562 µM and recoveries for the simulated agricultural environmental samples in the range of 94-115% suggests that the as-fabricated 2D Zn-MOF nanosheet colloidal sensor (Zn-LMOF probe) is a most promising candidate for sensing chemical pesticides.

Progress of research on disease-modifying osteoarthritis drugs / 中国药科大学学报

@#Osteoarthritis (OA) is a common chronic joint disease,whose main pathological changes are the degeneration of articular cartilage and secondary bone hyperplasia.The limitation of current treatment methods including pain relief and joint replacement surgery is that they cannot fundamentally improve the damage of articular cartilage.The emergence of disease-modifying osteoarthritis drugs (DMOAD) may break the above limitations.They fundamentally inhibit the structural degeneration of articular cartilage by participating in the regulation of cartilage metabolic balance, regulation of subchondral bone remodeling,and control of local inflammation.Thereby,OA patients will get symptom improvement including pain relief and joint function restoration,delay the artificial joint replacement surgery, and improve the quality of life. There are still no DMOAD drugs widely available on the market worldwide.This paper reviews the background of R&D,the classification of mechanisms of action and research progress of representative drugs under different inechanisms so as to provide reference for future research.

Study of the inflammatory response of immunocytes to polymerized porcine hemoglobin (pPolyHb).

Polymerized porcine hemoglobin (pPolyHb), which was synthesized from chemically modified porcine hemoglobin, can carry and deliver oxygen to tissues in addition to restoring intravascular volume. Assessment of the inflammatory response generated in the host is a part of the overall safety evaluation of pPolyHb. In this study, we measured the levels of IL-1ß, IL-10, and CD11b/CD18 in response to pPolyHb stimulation, both in vivo (in rats) and in vitro. Our results suggest that the levels of these indicators are not statistically changed by pPolyHb, indicating that pPolyHb is not immunotoxic to cells and animals in this respect.