Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 6 de 6
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Horm Metab Res ; 2024 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-37956980

RESUMO

The aim of this study is to report the risk factors of severe statin induced liver injury (SILI). From the database of Shandong ADR Monitoring Center and Outpatients and inpatients in our hospital, SILI cases reported from 2013 to 2021 were extracted and screened. The diagnostic criteria of SILI, the inclusion and exclusion criteria of severe and general SILI were established separately. After the SILI cases were selected and confirmed, the socio-demographic and clinical characteristics were collected. Single factor chi-square test and multi-factor unconditional logistic regression analysis were used to analyze the influencing factors of severe SILI. From 1391 reported cases, 1211 met SILI diagnostic criteria, of which 157 were severe SILI and 964 were general SILI. Univariate analysis showed that age, drug combination, statin category were the influencing factors of severe SILI (p<0.1). Multivariate logistic analysis showed that drug combination and statin category were the influencing factors of severe SILI (p<0.05). Atorvastatin caused the most serious SILI, and its risk is 1.77 times higher than rosuvastatin. The serious SILI risk of drug combination was 2.08 times higher than statin alone. The patient with these factors should be monitored intensively during clinical treatment, to ensure their medication safety.

2.
Chem Asian J ; 12(5): 515-523, 2017 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-28028932

RESUMO

Carbonyl-grafted g-C3 N4 porous nanosheets (COCNPNS) were fabricated by means of a two-step thermal process using melamine and oxalic acid as starting reagents. The combination of melamine with oxalic acid to form a melamine-oxalic acid supramolecule as a precursor is key to synthesizing carbonyl-grafted g-C3 N4 . The bulk carbonyl-grafted g-C3 N4 (COCN) was further thermally etched onto porous nanosheets by O2 under air. In such a process, the carbonyl groups were partly removed and the obtained sample showed remarkably enhanced visible-light harvesting and promoted the separation and transfer of photogenerated electrons and holes. With its unique porous structure and enhanced light-harvesting capability, under visible-light illumination (λ>420 nm) the prepared COCNPNS exhibited a superior photocatalytic hydrogen evolution rate of 83.6 µmol h-1 , which is 26 times that of the p-CN obtained directly from thermal polycondensation of melamine.

3.
CNS Neurosci Ther ; 20(11): 991-8, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25327787

RESUMO

BACKGROUND AND PURPOSE: The immunosuppressant drug rapamycin was reported to have an antiaging activity, which was attributed to the TORC1 inhibition that inhibits cell proliferation and increases autophagy. However, rapamycin also exhibits a number of harmful adverse effects. Whether rapamycin can be developed into an antiaging agent remains unclear. METHODS AND RESULTS: We demonstrated that rapamycin at micro-doses (below the TORC1 inhibiting concentration) exhibits a cell-protective activity: (1) It protects cultured neurons against neurotoxin MPP(+) and H2O2. (2) It increases survival time of neuron in culture. (3) It maintains the nonproliferative state of cultured senescent human fibroblasts and prevents cell death induced by telomere dysfunction. (4) In animal models, it decreased the cerebral infarct sizes induced by acute ischemia and dramatically extended the life span of stroke prone spontaneously hypertensive rats (SHR-SPs). CONCLUSION: We propose that rapamycin at micro-dose can be developed into an antiaging agent with a novel mechanism.


Assuntos
Envelhecimento/efeitos dos fármacos , Córtex Cerebral/efeitos dos fármacos , Imunossupressores/farmacologia , Sirolimo/farmacologia , Animais , Infarto Encefálico/etiologia , Infarto Encefálico/prevenção & controle , Isquemia Encefálica/complicações , Isquemia Encefálica/tratamento farmacológico , Morte Celular/efeitos dos fármacos , Linhagem Celular Transformada , Modelos Animais de Doenças , Fibroblastos/efeitos dos fármacos , Humanos , Peróxido de Hidrogênio/farmacologia , Masculino , Camundongos Endogâmicos C57BL , Fosforilação/efeitos dos fármacos , Ratos , Ratos Endogâmicos SHR , Ratos Sprague-Dawley , Transdução de Sinais/efeitos dos fármacos , Tacrolimo/farmacologia , beta-Galactosidase/metabolismo
4.
J Cereb Blood Flow Metab ; 33(6): 906-13, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23443169

RESUMO

Dietary restriction (DR) protects against neuronal dysfunction and degeneration, and reduces the risk of ischemic stroke. This study examined the role of silent information regulator T1 (SIRT1) and arterial baroreflex in the beneficial effects of DR against stroke, using two distinct stroke models: stroke-prone spontaneously hypertensive rats (SP-SHRs) and Sprague-Dawley (SD) rats with middle cerebral artery occlusion (MCAO). Sirt1 knockout (KO) mice were used to examine the involvement of sirt1. Sinoaortic denervation was used to inactivate arterial baroreflex. Dietary restriction was defined as 40% reduction of dietary intake. Briefly, DR prolonged the life span of SP-SHRs and reduced the infarct size induced by MCAO. Dietary restriction also improved the function arterial baroreflex, decreased the release of proinflammatory cytokines, and reduced end-organ damage. The beneficial effect of DR on stroke was markedly attenuated by blunting arterial baroreflex. Lastly, the infarct area in sirt1 KO mice was significantly larger than in the wild-type mice. However, the beneficial effect of DR against ischemic injury was still apparent in sirt1 KO mice. Accordingly, arterial baroreflex, but not sirt1, is important in the protective effect of DR against stroke.


Assuntos
Artérias/fisiopatologia , Barorreflexo , Restrição Calórica , Acidente Vascular Cerebral/prevenção & controle , Acidente Vascular Cerebral/fisiopatologia , Animais , Artérias/patologia , Pressão Sanguínea , Encéfalo/metabolismo , Encéfalo/patologia , Encéfalo/fisiopatologia , Citocinas/análise , Técnicas de Inativação de Genes , Infarto da Artéria Cerebral Média/genética , Infarto da Artéria Cerebral Média/patologia , Infarto da Artéria Cerebral Média/fisiopatologia , Infarto da Artéria Cerebral Média/prevenção & controle , Masculino , Camundongos , Camundongos Knockout , Ratos , Ratos Endogâmicos SHR , Ratos Sprague-Dawley , Sirtuína 1/genética , Acidente Vascular Cerebral/genética , Acidente Vascular Cerebral/patologia
5.
CNS Neurosci Ther ; 18(10): 834-40, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22925047

RESUMO

AIMS: To explore risk factors for stroke independent of hypertension and the relationship between riboflavin kinase (RFK) and stroke. METHODS: Gene expression profiling in the brains of spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHRSP) was comparatively analyzed by gene chips. The differentially expressed gene RFK was further verified by q-PCR and Western blot. The protective role of RFK-regulated flavins (including riboflavin, flavin mononucleotide, and flavin adenine dinucleotide) in stroke was observed in middle cerebral artery occlusion (MCAO) mice. Influence of flavins on apoptosis and death in oxygen and glucose deprivation (OGD)-treated neurons was examined by flow cytometry. Bax and Bcl-2 proteins were detected by Western blot. RESULTS: Of the 76 differentially expressed genes, 41 genes were upregulated, and 35 genes were downregulated in SHRSP as compared with SHR. RFK was significantly downregulated in SHRSP. Flavins markedly decreased infarct area in MCAO mice, inhibited apoptosis and death in OGD-treated neurons, and decreased Bax protein expression. CONCLUSIONS: Physiological downregulation of RFK may be a new potential risk factor for stroke, which probably affects the absorbance and utility of riboflavin and further destroys the protective effect of flavins on stroke. RFK might act as a therapeutic target for stroke.


Assuntos
Regulação Enzimológica da Expressão Gênica/fisiologia , Infarto da Artéria Cerebral Média , Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo , Análise de Variância , Animais , Apoptose/efeitos dos fármacos , Infarto Encefálico/etiologia , Infarto Encefálico/prevenção & controle , Células Cultivadas , Córtex Cerebral/citologia , Dinitrocresóis/uso terapêutico , Modelos Animais de Doenças , Embrião de Mamíferos , Citometria de Fluxo , Perfilação da Expressão Gênica , Glucose/deficiência , Hipóxia/genética , Hipóxia/patologia , Infarto da Artéria Cerebral Média/genética , Infarto da Artéria Cerebral Média/metabolismo , Infarto da Artéria Cerebral Média/patologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Fármacos Neuroprotetores/uso terapêutico , Análise de Sequência com Séries de Oligonucleotídeos , Fosfotransferases (Aceptor do Grupo Álcool)/genética , Proteínas Proto-Oncogênicas c-bcl-2/genética , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Ratos , Ratos Endogâmicos SHR , Proteína X Associada a bcl-2/genética , Proteína X Associada a bcl-2/metabolismo
6.
J Cardiovasc Pharmacol ; 57(3): 308-16, 2011 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21266915

RESUMO

AIM: This study was designed to investigate the effects of telmisartan and amlodipine on reduction of blood pressure (BP), myocardial hypertrophy, and renal injury in hypertensive rats. METHOD: In acute experiments, the BP was measured in conscious freely moving rats. Spontaneously hypertensive rats were treated with intragastric administration of amlodipine (1, 2, 4 mg/kg), telmisartan (4, 8, 12, 16, 20 mg/kg), and their different combinations (4 + 4, 2 + 4, 4 + 8, 4 + 12, 1 + 4, 2 + 8, 4 + 16, 2 + 12, 1 + 8, 2 + 16, 2 + 20, 1 + 12, 1 + 16, 1 + 20 mg/kg). The probability sum test (q test) was used to evaluate the synergistic action on BP reduction. In two-kidney, one-clip rats, the effects of amlodipine (1 mg/kg), telmisartan (6 mg/kg) and their combination on BP reduction were observed. In the chronic study, spontaneously hypertensive rats were treated with amlodipine (1 mg/kg), telmisartan (6 mg/kg), and their combination for 4 months. Histopathologic examinations were performed after the determination of BP and BP variability. RESULTS: There is a synergistic interaction between amlodipine and telmisartan on BP reduction. The optimal dose ratio was found at 1:6. The synergistic effect of this dose ratio (1:6) was also seen in two-kidney, one-clip rats. Long-term treatment with this combination results in a beneficial effect on the reduction of BP and BP variability. The end-organ damage, including myocardial hypertrophy, glomerular atrophy, and fibrosis, was significantly attenuated by this combination. CONCLUSION: The optimal dose ratio of amlodipine and telmisartan on BP was 1:6. This combination is beneficial for the BP and BP variability reduction and end-organ damage prevention.


Assuntos
Anlodipino/uso terapêutico , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Anti-Hipertensivos/uso terapêutico , Benzimidazóis/uso terapêutico , Benzoatos/uso terapêutico , Bloqueadores dos Canais de Cálcio/uso terapêutico , Cardiotônicos/uso terapêutico , Hipertensão/tratamento farmacológico , Animais , Pressão Sanguínea/efeitos dos fármacos , Pressão Sanguínea/fisiologia , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Sinergismo Farmacológico , Quimioterapia Combinada , Hipertensão/fisiopatologia , Rim/efeitos dos fármacos , Rim/fisiopatologia , Nefropatias/prevenção & controle , Glomérulos Renais/efeitos dos fármacos , Masculino , Ratos , Ratos Endogâmicos SHR , Ratos Sprague-Dawley , Telmisartan , Fatores de Tempo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...