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1.
Adv Sci (Weinh) ; 11(10): e2307746, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38145346

RESUMO

Electrical stimulation (ES) is proposed as a therapeutic solution for managing chronic wounds. However, its widespread clinical adoption is limited by the requirement of additional extracorporeal devices to power ES-based wound dressings. In this study, a novel sandwich-structured photovoltaic microcurrent hydrogel dressing (PMH dressing) is designed for treating diabetic wounds. This innovative dressing comprises flexible organic photovoltaic (OPV) cells, a flexible micro-electro-mechanical systems (MEMS) electrode, and a multifunctional hydrogel serving as an electrode-tissue interface. The PMH dressing is engineered to administer ES, mimicking the physiological injury current occurring naturally in wounds when exposed to light; thus, facilitating wound healing. In vitro experiments are performed to validate the PMH dressing's exceptional biocompatibility and robust antibacterial properties. In vivo experiments and proteomic analysis reveal that the proposed PMH dressing significantly accelerates the healing of infected diabetic wounds by enhancing extracellular matrix regeneration, eliminating bacteria, regulating inflammatory responses, and modulating vascular functions. Therefore, the PMH dressing is a potent, versatile, and effective solution for diabetic wound care, paving the way for advancements in wireless ES wound dressings.


Assuntos
Diabetes Mellitus , Hidrogéis , Humanos , Biomimética , Proteômica , Cicatrização , Bandagens
2.
Analyst ; 146(22): 6815-6821, 2021 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-34643194

RESUMO

Solid-state nanochannels have attracted considerable attention for their similar ion transport properties to biological ion channels. The construction of porous ion channels with good stability at the submicro/micrometer scale is very beneficial to develop large-area ion channel devices. In this manuscript, based on in-situ thermal crosslinking of a small organic molecule containing triphenylamine and styrene groups, we construct a heterogeneous membrane with asymmetrical charge and wettability on cylindrical anodic aluminum oxide (AAO) channels (D ≈ 319 nm). This heterogeneous membrane has typical ion current rectification characteristics with a high rectification ratio of 36.9 and good stability. This work provides an effective strategy for the construction of submicrochannel heterogeneous membranes and also broadens the application range of bionic ion channels.


Assuntos
Força Próton-Motriz , Transporte de Íons , Porosidade , Molhabilidade
3.
Sci Adv ; 6(39)2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32967829

RESUMO

As a superior self-protection strategy, invisibility has been a topic of long-standing interest in both academia and industry, because of its potential for intriguing applications that have only appeared thus far in science fiction. However, due to the strong dispersion of passive materials, achieving cross-wavelength invisibility remains an open challenge. Inspired by the natural ecological relationship between transparent midwater oceanic animals and the cross-wavelength detection strategy of their predators, we propose a cross-wavelength invisibility concept that integrates various invisibility tactics, where a Boolean metamaterial design procedure is presented to balance divergent material requirements over cross-scale wavelengths. As proof of concept, we experimentally demonstrate longwave cloaking and shortwave transparency simultaneously through a nanoimprinting technique. Our work extends the concept of stealth techniques from individual invisibility tactics targeting a single-wavelength spectrum to an integrated invisibility tactic targeting a cross-wavelength applications and may pave the way for development of cross-wavelength integrated metadevices.

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