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1.
Arch. med. deporte ; 35(183): 29-34, ene.-feb. 2018. tab, graf
Artigo em Inglês | IBECS | ID: ibc-177441

RESUMO

Introduction: Sports induce morphological and functional adaptations in the human heart that directly relate to the type, duration and intensity of training and the years of practice. These changes are present in different ways in the electrocardiogram. A high QRS voltage is the most significant finding. Its correlation with left ventricular hypertrophy is low. In this study, the aim was to determine if a relationship exists between electrocardiographic alterations of left ventricular hypertrophy and somatotype in high performance athletes. Methods: A retrospective, cross-sectional, quantitative, multiple correlation, observational and analytical study of a database of 180 resting electrocardiograms and anthropometric evaluations of men's soccer, women's soccer, swimming, cycling, basketball, and tennis athletes was performed. A database containing somatotype and Sokolow-Lyon electrocardiographic voltage criteria was created. Results: The study group was composed of 83.3% men and 16.7% women. Age ranged from 10 to 51 years with a mean of 19.73 ± 5.8. Weight ranged from 35.90 to 122.3 kg with a mean of 66.98 ± 12.67 and height ranged from 143 to 213 cm with a mean of 174.11 ± 10.29 cm. Endomorphy for the entire group ranged from 1.0 to 5.7 with a mean of 2.5 ± 0.9. Mesomorphy ranged from 1.6 to 7.1 with a mean of 4.2 ± 0.95. Ectomorphy ranged from 1.1 to 5.8 with a mean of 2.9 ± 0.96. The structural equation model had a normal multivariable distribution of 3.161, reaching a Pearson of .26 for mesomorphy with a goodness of fit and a variance of 0% for mesomorphy and left ventricular hypertrophy. Conclusion: Based on the findings, we can say that somatotype does not predict left ventricular hypertrophy in high per-formance athletes


Introducción: Los deportes inducen adaptaciones morfológicas y funcionales en el corazón humano directamente relacionadas con el tipo, duración e intensidad del entrenamiento y los años de práctica. Estos cambios se manifiestan de diversas formas en el electrocardiograma. Un alto voltaje del QRS es el hallazgo más significativo. Su correlación con la hipertrofia ventricular izquierda es baja. En este estudio, el objetivo era determinar si existe una relación entre las alteraciones electrocardiográficas de hipertrofia ventricular izquierda y el somatotipo en deportistas de alto rendimiento. Métodos: Se efectuó un estudio transversal, cuantitativo, observacional, analítico retrospectivo de correlación múltiple de una base de datos de 180 electrocardiogramas en reposo y antropometría de atletas de soccer varonil, soccer femenil, natación, basquetbol, ciclismo y tenis. Se creó una base de datos con el somatotipo y los criterios de voltaje electrocardiográfico de Sokolow-Lyon. Resultados: El grupo de estudio estaba compuesto por 83,3% varones y 16,7% mujeres. El rango de edad fue de 10 a 51 años con una media de 19,73 ± 5,8. El peso varió de 35,90 a 122,3 kg con una media de 66,98 ± 12,67 y la estatura varió de 143 a 213 cm con una media de 174,11 ± 10,29 cm. Endomorfia para todo el grupo osciló entre 1,0 y 5,7 con una media de 2,55 ± 0,9. Mesomorfia varió de 1,6 a 7,1 con una media de 4,2 ± 0,95. Ectomorfia varió de 1,1 a 5,8 con una media de 2,9 ± 0,96. El modelo de ecuaciones estructurales tenía una distribución multivariable normal de 3.161, alcanzando un Pearson de 0,26 para mesomorfia con una bondad de ajuste y una varianza de 0% para mesomorfia e hipertrofia ventricular izquierda. Conclusiones: En base a los hallazgos podemos decir que el somatotipo no predice hipertrofia ventricular izquierda en atletas de alto rendimiento


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Hipertrofia Ventricular Esquerda/genética , Modelos Estruturais , Desempenho Atlético/fisiologia , Somatotipos/fisiologia , Tecnologia Educacional , Estudos Transversais , Estudos Retrospectivos , Antropometria
2.
Org Biomol Chem ; 13(2): 527-38, 2015 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-25378061

RESUMO

A library of azonia aromatic cations has been studied in order to gain insights into the effect of the size, shape and charge distribution on the fluorescence, DNA interactions and DNA sequence selectivity properties. Fluorescence-based thermal denaturation experiments, spectrofluorimetric titrations, circular dichroism measurements and theoretical simulations have shown that some of the studied chromophores have interesting fluorescence properties and two of them also show a consistent DNA-binding ability by intercalation, with a potential preference for AT-rich sequences.


Assuntos
DNA/química , Cátions/química , Dicroísmo Circular , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Simulação de Dinâmica Molecular , Desnaturação de Ácido Nucleico , Espectrometria de Fluorescência
3.
Eur J Med Chem ; 61: 2-25, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22749189

RESUMO

The TAM subfamily of Receptor Tyrosine Kinases (RTKs) contains three human proteins of therapeutical interest, Axl, Mer, and Tyro3. Our goal was to design a type II inhibitor specific for this family, i.e. able to interact with the allosteric pocket and with the hinge region of the kinase. We report the synthesis of several series of purine analogues of BMS-777607. The structural diversity of the designed inhibitors was expected to modify the interactions formed in the binding site and consequently to modulate their selectivity profiles. The most potent inhibitor 6g exhibits Kds of 39, 42, 65 and 200 nM against Axl, Mer, Met and Tyro3 respectively. Analysis of the affinity of 6g for active and inactive forms of Abl1, an RTK protein that does not belong to the TAM subfamily, together with the binding modes of 6g predicted by docking studies, indicates that 6g displays some selectivity for the TAM family and may act as a type II inhibitor.


Assuntos
Inibidores de Proteínas Quinases/síntese química , Inibidores de Proteínas Quinases/farmacologia , Receptores Proteína Tirosina Quinases/antagonistas & inibidores , Animais , Células Cultivadas , Chlorocebus aethiops , Relação Dose-Resposta a Droga , Humanos , Modelos Moleculares , Estrutura Molecular , Inibidores de Proteínas Quinases/química , Receptores Proteína Tirosina Quinases/metabolismo , Relação Estrutura-Atividade , Células Vero
4.
Molecules ; 17(8): 8735-41, 2012 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-22832875

RESUMO

The synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6H-purin-6-one, a minor impurity of acyclovir, is described. Starting with commercial N-(9-acetyl-6-oxo-1H-purin-2-yl)acetamide, the process uses an acid catalysed phase transfer catalysis (PTC) process to produce the selective alkylation at the 9 position of the guanine ring.


Assuntos
2-Aminopurina/análogos & derivados , Aciclovir/síntese química , Contaminação de Medicamentos , 2-Aminopurina/síntese química , Alquilação , Benzenossulfonatos/química , Catálise , Etilenoglicol/química , Formaldeído/química , Ácido Clorídrico/química , Polímeros/química , Compostos de Amônio Quaternário/química
5.
Chemistry ; 16(32): 9746-9, 2010 Aug 23.
Artigo em Inglês | MEDLINE | ID: mdl-20672258
6.
Resuscitation ; 75(3): 530-3, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17709165

RESUMO

An emergency thoracotomy (ET) is a surgical procedure rarely practiced outside a hospital. However, it can be the only way to resuscitate a patient who has suffered cardiac arrest due to penetrating chest trauma. SAMUR-Protección Civil is a two-tier Emergency Medical Service of Madrid, with Advance Life Support teams led by Emergency Physicians, Emergency Nurses and Paramedics. Over the last 3 years, medical teams from SAMUR have performed ET in six cases, after a short period of cardiac arrest, restoring cardiac output in two cases, and one patient with a normal neurological outcome. The following SAMUR protocol describes these emergency situations and details the case of the patient who was treated and discharged from hospital without any repercussions.


Assuntos
Serviços Médicos de Emergência/métodos , Parada Cardíaca/terapia , Massagem Cardíaca/métodos , Toracotomia , Adulto , Tamponamento Cardíaco/etiologia , Tamponamento Cardíaco/terapia , Parada Cardíaca/etiologia , Humanos , Masculino , Traumatismos Torácicos/complicações , Toracotomia/ética , Toracotomia/métodos , Toracotomia/estatística & dados numéricos , Fatores de Tempo , Ferimentos Perfurantes/complicações
7.
Org Biomol Chem ; 3(5): 729-31, 2005 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-15731855

RESUMO

Optically active vinyl triflates are obtained and employed in a series of one pot metal-catalyzed tandem asymmetric transformations.

8.
Org Biomol Chem ; 2(24): 3584-7, 2004 Dec 21.
Artigo em Inglês | MEDLINE | ID: mdl-15592616

RESUMO

Enantiomerically pure natural and unnatural alpha-amino acids have been synthesized from a chiral methyleneoxazolidinone by means of a highly diastereoselective 1,4-conjugate addition of alkyl iodides in aqueous media. The zinc-copper conjugate addition reaction exhibits high chemoselectivity, with the possibility of using functionalized iodides, to afford a single diastereomer in short reaction times and with good yields.


Assuntos
Aminoácidos/síntese química , Água/química , Conformação Molecular , Estereoisomerismo
9.
J Steroid Biochem Mol Biol ; 89-90(1-5): 19-23, 2004 May.
Artigo em Inglês | MEDLINE | ID: mdl-15225740

RESUMO

The synthesis of vitamin D(3) active metabolites [24R,25-(OH)(2)-D(3), 24S,25-(OH)(2)-D(3) and 1alpha,24R,25-(OH)(3)-D(3)] and the first 24-aminovitamin D(3) derivatives [24S-benzoylamino-25-OH-D(3) and 24S-benzoylamino-1alpha,25-(OH)(2)-D(3)] are reported. The stereogenic center at C-24 was generated through ultrasonically induced aqueous conjugate addition of iodide 8 to dioxolanone 6 or oxazolidinone 7. The vitamin D triene system was constructed using the Lythgoe approach. The synthetic route, which is both short (6 or 7 steps from iodide 8) and efficient (32-45% overall yield), constitutes a practical method for the preparation of 24-functionalized metabolites and analogues of vitamin D(3). The ultrasonically induced conjugate addition in the key step provides a novel example of a highly stereoselective reaction promoted by the zinc-copper couple in aqueous media.


Assuntos
Vitamina D/análogos & derivados , Estereoisomerismo , Vitamina D/síntese química , Vitamina D/metabolismo
10.
Chemistry ; 9(17): 4179-87, 2003 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-12953203

RESUMO

The stereoselectivity of the ultrasonically induced zinc--copper conjugate addition of iodides to chiral alpha,beta-unsaturated carbonyl systems under aqueous conditions was studied. Alkyl iodides add diastereoselectively to methylenedioxolanone 1 and methyleneoxazolidinone 2 to afford the 1,4-addition products in good yields (38-95 %) and with high diastereomeric excess (44-90 % de). The 1,4-addition to chiral gamma,delta-dioxolanyl-alpha,beta-unsaturated esters 3-5 also proceeds with good yields (51-99 %). The diastereoselectivity is dependent on the geometry of the olefin: the Z isomer 3 gives high diastereoselectivity, while the reactions with the E isomer 4 are nonstereoselective. The reaction proceeds with excellent chemoselectivity and allows the use of iodides bearing ester, hydroxy, and amino groups. Since the 1,4-addition products can be readily hydrolyzed, this methodology constitutes a novel entry for the enantioselective synthesis of alpha- and gamma-hydroxy acids and alpha-amino acids in aqueous media. The results obtained support the radical mechanism proposed by Luche, and represent one of the few examples of a radical stereoselective conjugate addition in aqueous medium.


Assuntos
Aminoácidos/síntese química , Hidroxiácidos/síntese química , Água/química , Aminoácidos/química , Cobre/química , Ésteres/química , Hidrocarbonetos Iodados/química , Hidroxiácidos/química , Oxazolidinonas/química , Estereoisomerismo , Zinco/química
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