Biodegradable cotton fiber-based piezoresistive textiles for wearable biomonitoring.

Electronic textiles are fundamentally changing the way we live. However, the inability to effectively recycle them is a considerable burden to the environment. In this study, we developed a cotton fiber-based piezoresistive textile (CF p-textile) for biomonitoring which is biocompatible, biodegradable, and environmentally friendly. These CF p-textiles were fabricated using a scalable dip-coating method to adhere MXene flakes to porous cotton cellulose fibers. The adhesion is made stronger by strong hydrogen bonding between MXene flakes and hierarchically porous cotton cellulose fibers. This cotton-fiber system provides a high sensitivity of 17.73 kPa-1 in a wide pressure range (100 Pa-30 kPa), a 2 Pa subtle pressure detection limit, fast response/recovery time (80/40 ms), and good cycle stability (over 5, 000 cycles). With its compelling sensing performance, the CF p-textile can detect various human biomechanical activities, including pulsation, muscle movement, and swallowing, while still being comfortable to wear. Moreover, the cotton cellulose is decomposed into low-molecular weight cellulose or glucose as a result of the 1,4-glycosidic bond breakage when exposed to acid or during natural degradation, which allows the electronic textile to be biodegradable. This work offers an ecologically-benign, cost-effective and facile approach to fabricating high-performance wearable bioelectronics.

RecBCD enzyme and Chi recombination hotspots as determinants of self vs. non-self: Myths and mechanisms.

Bacteria face a challenge when DNA enters their cells by transformation, mating, or phage infection. Should they treat this DNA as an invasive foreigner and destroy it, or consider it one of their own and potentially benefit from incorporating new genes or alleles to gain useful functions? It is frequently stated that the short nucleotide sequence Chi (5' GCTGGTGG 3'), a hotspot of homologous genetic recombination recognized by Escherichia coli's RecBCD helicase-nuclease, allows E. coli to distinguish its DNA (self) from any other DNA (non-self) and to destroy non-self DNA, and that Chi is "over-represented" in the E. coli genome. We show here that these latter statements (dogmas) are not supported by available evidence. We note Chi's wide-spread occurrence and activity in distantly related bacterial species and phages. We illustrate multiple, highly non-random features of the genomes of E. coli and coliphage P1 that account for Chi's high frequency and genomic position, leading us to propose that P1 selects for Chi's enhancement of recombination, whereas E. coli selects for the preferred codons in Chi. We discuss other, previously described mechanisms for self vs. non-self determination involving RecBCD and for RecBCD's destruction of DNA that cannot recombine, whether foreign or domestic, with or without Chi.