[Cytotoxic activity of blood serum in borderline conditions]. / Tsitotoksicheskaia aktivnost' syvorotki krovi pri pogranichnykh sostoianiiakh.

A study was made of cytotoxic activity of blood serum from 118 patients with borderline neuropsychic disorders (neurotic depression, neurosis, psychopathy, pathologic development of the personality on the basis of organic injury to the brain). Material of 114 mentally and somatically healthy donors served as control. Balb mouse thymocytes and organ culture of the rat brain were employed as test objects. ++Anti-thymus activity (ATA) was measured according to the cytotoxic index, whereas neurotoxic activity (NTA) by inhibition of 3H-cholesterol incorporation. The patients and donors groups differed by distribution of persons with high and low values of NTA and ATA. However, according to the mean level of blood serum cytotoxic activity such a difference was revealed only in respect to NTA. The determined parameters are related in a different way to the patient's age and similarly to the disease standing. The intensity of ATA and NTA was different in different nosological subgroups. An interrelationship was established between the clinical and biological dynamics, supporting a possibility of the use of the given tests as predictors of the therapeutic efficacy and the depth of homeostasis derangement.

[Social and occupational adaptation of patients with borderline disorders of endogenous-organic origin at a large industrial enterprise]. / Sotsial'no-proizvodstvennaia adaptatsiia bol'nykh s pogranichnymi rasstroiatvami ékzogenno-organicheskogo geneza na krupnom promyshlennom predpriiatii.

The authors examined 287 patients who developed neurosis-like and psychopathy-like disorders 1-15 years after the experienced exogenous organic diseases (brain traumas, vascular diseases and infectious-toxic diseases). In the assessment of adaptation under conditions of a large industrial enterprise the factors under consideration were: the patient's attitude to his fellow workers and superiors, participation in social work, the attitude of the fellow-workers and superiors to the patient, etc. Four levels of adaptation were identified: (1) complete stable; (2) incomplete professional; (3) incomplete psychological; (4) incomplete unstable (formal). The level of adaptation and the nature of mental disorders were found to correlate. The elucidated regularities may serve as a basis for elaborating rehabilitative programmes for individual groups of patients.

[Evaluation of the classification of pathological personality development of exogenous organic origin by the main component method]. / Otsenka sistematiki patologicheskogo razvitiia lichnosti ékzogenno-organicheskogo geneza metodom glavnykh komponent.

The author has tested the developed classification of the pathological personality development of the exogenic-organic genesis using the method of main components. On the basis of the mathematical processing of clinical symptomatology in 348 patients with various types of the pathological development (asthenic, hysteriform, hypochondriac, explosive) the author has defined three main components: "excitability", "inhibition" and "hypochondriac anger". An analysis of the distributional pattern of types of the pathological personality development in orthogonal planes of three main components has made it possible to establish the adequacy of the proposed classification of the internal structure of the disease and identify the variants appearing as "unifying" and "distinguishing" borderlines between individual types.