CC chemokine ligand 3 and receptors 1 and 5 gene expression in recurrent aphthous stomatitis.

OBJECTIVE: The aim of this study was to investigate the local and systemic expression of CC-chemokine ligand 3 (CCL3) and its receptors (CCR1 and CCR5) in tissue samples and peripheral blood mononuclear cells of recurrent aphthous stomatitis (RAS) patients. STUDY DESIGN: This case-control study enrolled 29 patients presenting severe RAS manifestations and 20 non-RAS patients proportionally matched by sex and age. Total RNA was extracted from biopsy specimens and peripheral blood mononuclear cells for quatitative reverse-transcription polymerase chain reaction. The data obtained by relative quantification were evaluated by the 2(-ΔΔCt) method, normalized by the expression of an endogenous control, and analyzed by Student t test. RESULTS: The results demonstrated overexpression in RAS tissue samples of all of the chemokines evaluated compared with healthy oral mucosa, whereas the blood samples showed only CCR1 overexpression in RAS patients. CONCLUSIONS: These findings suggest that the increased expression of CCL3, CCR1, and CCR5 may influence the immune response in RAS by T(H)1 cytokine polarization.

Risk factors for oral squamous cell carcinoma in young and older Brazilian patients: a comparative analysis.

OBJECTIVES: The aim of this study was to investigate risk factors and clinical aspects associated with oral squamous cell carcinoma (OSCC) in young patients as compared to older ones. STUDY DESIGN. Data was obtained by retrospective analysis of files of patients with OSCC, who were categorised into two groups: the young group (< or =40 years old) and the older group (> 40 years old). Clinical data, including habits, familial antecedents, medical records and occupation were collected. RESULTS: One hundred and twenty-one patients were found to have OSCC; 13 (10.7%) were young individuals and 108 (89.3%) older ones. Consumption of tobacco and/or alcohol was reported by 7 (53.8%) young patients and by 81 (75.0%) older patients, this difference not being statistically significant (P = 0.18). However, only 1 young patient (12.5%) was a heavy consumer of tobacco and alcohol as opposed to 49 (60.5%) of the older patients. Familial antecedents of malignant neoplasm were reported by 11 (84.6%) young patients and 32 (29.6%) older ones respectively, this difference being statistically significant (P = 0.0001). Medical records and patient's occupation did not show correlation with the aetiology of OSCC. CONCLUSION: Although the young and older patients share a similar habit for the consumption of tobacco and/or alcohol, the pattern of consumption and time of exposure to these two risk factors suggested that these etiologic factors are less clearly implicated in the development of oral cancer in the young patients than in older ones. Thus, for young patients with OSCC, the search for predisposing factors should assign greater weight to familial antecedents of malignant neoplasm.

Risk factors for oral squamous cell carcinoma in young and older Brazilian patients: A comparative analysis

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Objectives. The aim of this study was to investigate risk factors and clinical aspects associated with oral squamous cell carcinoma (OSCC) in young patients as compared to older ones.Study design. Data was obtained by retrospective analysis of files of patients with OSCC, who were categorised into two groups: the young group (¡Ü40 years old) and the older group (> 40 years old). Clinical data, including habits, familial antecedents, medical records and occupation were collected.Results. One hundred and twenty-one patients were found to have OSCC; 13 (10.7%) were young individuals and108 (89.3%) older ones. Consumption of tobacco and/or alcohol was reported by 7 (53.8%) young patients and by81 (75.0%) older patients, this difference not being statistically significant (P = 0.18). However, only 1 young patient (12.5%) was a heavy consumer of tobacco and alcohol as opposed to 49 (60.5%) of the older patients. Familial antecedents of malignant neoplasm were reported by 11 (84.6%) young patients and 32 (29.6%) older ones respectively, this difference being statistically significant (P = 0.0001). Medical records and patient¡¯s occupation did not show correlation with the aetiology of OSCC.Conclusion. Although the young and older patients share a similar habit for the consumption of tobacco and/oralcohol, the pattern of consumption and time of exposure to these two risk factors suggested that these etiologicfactors are less clearly implicated in the development of oral cancer in the young patients than in older ones. Thus, for young patients with OSCC, the search for predisposing factors should assign greater weight to familial antecedents of malignant neoplasm

Carcinoma epidermóide oral em paciente jovem: relato de caso e revisão da literatura / Oral squamous cell carcinoma in a young patient: case report and literature review

O carcinoma epidermóide constitui a neoplasia maligna mais comum da boca, afetando principalmente indivíduos com mais de 50 anos. Sua ocorrência em jovens, com idade inferior a 40 anos, é rara (1 a 6 por cento dos casos). Descreve-se um caso de carcinoma epidermóide acometendo dorso e borda da língua, classificado como T2N1M0 (estádio III), em paciente do sexo feminino, leucoderma, 25 anos, não-fumante e não-etilista. A apresentação inicial do caso era de ulceração profunda com dor intensa. Fatores predisponentes locais e gerais, diagnóstico diferencial e prognóstico são discutidos, bem como a revisão da literatura referente a diversos aspectos do carcinoma epidermóide em jovens.

Periodontal aspects of the juvenile from form of paracoccidioidomycosis

Tres casos da forma juvenil da paracoccidioidomicose säo relatados. Especial enfase foi dada com relaçäo as manifestaçöes bucais, particularmente no que diz respeito ao envolvimento periodontal. Os principais achados periodontais foram: destruiçäo progressiva e generalizada do osso alveolar causando acentuada retraçäo gengival e exposiçäo das raizes dentarias. Mobilidade dentaria e perda espontanea de alguns dentes constituiram também sinais clinicos importantes. A mucosa gengival apresentava-se lisa, eritematosa e superficialmente edemaciada. Pequenas areas de ulceraçäo com finas granulaçöes foram observadas na gengiva de um dos pacientes. Estes aspectos, embora raros, podem representar os primeiros sinais da paracoccidioidomicose juvenil e, as vezes, sua única manifestaçäo