RESUMO
We compared antibacterial activity of various extracts of two licorice subspecies against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis. Diethyl carbonate extracts of Glycyrrhiza glabra root from Astrakhan region (Russia) exhibited maximum activity against the test microbial strains; activity of Astrakhan licorice was superior among 50% ethanol extracts from Astrakhan (Russia) and Calabria (Italy). Antibacterial activity is directly proportional to the content of glycyrrhizin and 18ß-glycyrrhetinic acid in the extracts. According to preliminary data, the content of these chemical components in Glycyrrhiza glabra root from Astrakhan region is higher than in licorice growing in Italy, which is presumably related to climate and geographic characteristics of Astrakhan region.
Assuntos
Antibacterianos/farmacologia , Glycyrrhiza/química , Extratos Vegetais/análise , Raízes de Plantas/química , Antibacterianos/análise , Bacillus subtilis/efeitos dos fármacos , Dietil Pirocarbonato/análogos & derivados , Escherichia coli/efeitos dos fármacos , Etanol , Ácido Glicirretínico/análogos & derivados , Ácido Glicirretínico/química , Ácido Glicirretínico/farmacologia , Glycyrrhiza/genética , Ácido Glicirrízico/química , Ácido Glicirrízico/farmacologia , Itália , Estrutura Molecular , Extratos Vegetais/farmacologia , Federação Russa , Staphylococcus aureus/efeitos dos fármacosRESUMO
Diagnostic test systems for the detection of IgG and IgM to Mycobacterium leprae in the blood sera of leprosy patients and armadillos experimentally infected with M. leprae have been developed on the basis of the indirect immunoperoxidase assay. The possibility has been shown of prognosing the activity of the leprotic process in leprosy patients and the results of the experimental infection of armadillos by the dynamic increase of antibody reactions with the development of the infection.
