[Effects of sera from patients with amyotrophic lateral sclerosis on neural tissue in vivo and in vitro]. / Osobennosti vliianiia syvorotok bol'nykh bokovym amiotroficheskim sklerozom na nervnuiu tkan' in vivo and in vitro.

Sera from patients with lateral amyotrophic sclerosis (LAS) were discovered to produce a cytotoxic effect one hour after their intracerebral administration to experimental animals. Coons' test using serum against human gammaglobulins was used to detect their selective binding to separate cells of nervous tissue culture. The data obtained point out that LAS patients' serum contains different anticerebral antibodies whose presence may account for the cytotoxic effect of these sera on the ultrastructure of experimental animals' nervous tissue.

[Features of the ultrastructure of the brain tissue of Meriones unguiculatus after cerebral ischemia and postischemic recirculation]. / Osobennosti ul'trastruktury tkani mozga mongol'skikh peschanok v usloviiakh ishemii mozga i postishemicheskoi retirkuliatsii.

The authors studied the ultrastructure of the brain tissue in "symptom negative" clawed jirds (M. unguiculatus) in the presence of permanent and transient circulatory ischemia caused by ligation of the right common carotid artery and by a 3-minute occlusion of the left common carotid artery which was unattended by any clinical manifestations signifying cerebral ischemia. The formation of oedema and dystrophic changes in the right hemisphere differed from that in the left one. Permanent ischemia was associated with the typical picture of hypoxic damage to the neural tissue with the development of cytotoxic oedema. Transient ischemia was predominantly characterized by an impairment of the blood-brain barrier with the development of marked vasogenic oedema. The study made it possible to closely follow the differences in the formation of an early stage of brain damage in permanent and transient ischemia and to establish the possibility of the damaging effect of blood recirculation in the hemisphere previously affected with ischemia.

[Features of the effect of the sera of patients with hepatocerebral dystrophy on nerve tissue in vivo and in vitro]. / Osobennosti vliianiia syvorotok bol'nykh gepatotserebral'noi distrofiei na nervnuiu tkan' in vivo i in vitro.

Electron microscopy of normal rabbit brain, conducted after the animals had been given intracerebral injection of serum obtained from patients with hepatocerebral dystrophy revealed some peculiarities of the damaging effect of such serum on the brain. Incubation of neural tissue culture with such serum resulted in appearance of hypertrophic astrocytes, type II Alzheimer's cells and Opalski's cells combined with the intact synthesis of an astrocyte specific antigen--an acid protein of astrocytic fibrility--detected by Coons' immunofluorescent test.

[Effect of different doses of dexamethasone on the course of brain injuries in animals sensitized to nerve tissue antigens]. / Vliianie razlichnykh doz deksametazona na techenie travmy mozga u zhivotnykh, sensibilizirovannykh k antigenam nervnoi tkani.

The effect of different dexamethasone doses on the development of edema of the brain in its injury was studied on 79 rabbits, controls and those sensitized with the brain antigen. The local cerebral circulation and the total tissue fluid in the perifocal region of the injured grey and white matter of the rabbit's cerebral hemispheres were studied; EEG was recorded and ultrastructural study of the nervous tissue in the zone of the trauma at the level of the ultrastructures was conducted. The examination showed that dexamethasone had a favourable therapeutic effect on the course of the brain trauma in the early periods after it was inflicted; the agent reduced edema of the brain tissue, which was especially manifest in animals with altered immunological reactivity of the organism. The best effect in these animals was caused by large doses of dexamethasone.

[Nerve tissue ultrastructure in experimental brain injuries in animals with increased immunobiologic reactivity following treatment with certain desensitizing drugs]. / Ul'trastruktura nervnoi tkani pri éksperimental'noi travme mozga u zhivotnykh s povyshennoi immunobiologicheskoi reaktivnost'iu organizma pri vozdeistvii nekotorykh desensibiliziruiushchikh preparatov.

The effects of aminazin and aspirin on brain injuries in animals with immunological hypersensitivity of the body were studied. It was shown that the ultrastructural changes of the nervous tissue and the edema in the perifocal zone of the injury at early periods after ist inflicting were less marked in those animals than in sensitized animals which received no preliminary drug treatment. The capacity of aminazin and aspirin to inhibit the activity of oxidative enzymes, probably, creates conditions in which the development of the dystrophic changes is delayed. This is important for further development and course of the pathological process. Examinations of the aspirin effect under the conditions of the experiment revealed its inhibitory role in the formation of the antigen-antibody complex in the zone of the injury. Taking into account possible sensitization of the body even in clinically healthy persons one can hope that the use of desensitizing drugs may contribute to diminution of brain edema and the morphological changes resulting from surgical interventions in some diseases of the nervous system.

[Ultrastructural features of cerebral nervous tissue under conditions of specific sensitization and desensitization of the body]. / Ul'trastrukturnye osobennosti nervnoi tkani golovnogo mozga v usloviiakh spetsificheskoi sensibilizatsii i desensibilizatsii organizma

On the basis of a study of the ultrastructural traits of the brain matter under conditions of specific sensitization and desensitization of the organism, the author comes to the following conclusion. A sensitization of the organism by brain antigens is accompanied by a physiological activation of the nervous system cells, especially of their defense mechanisms. In specific desensitization when it is considered that there is a disappearance of increased sensitivity of the organism, an electronomicroscopic study of the brain revealed an expressed activation of the ultrastructures, both in the nervous and glial elements of the brain tissue.