RESUMO
BACKGROUND: The complications associated with the use of systemic corticosteroid therapy have prompted a search for alternative agents. However, these agents are themselves associated with increased risk of myelosuppression or malignancy. METHODS: The present study included twenty patients with recalcitrant pemphigus or steroid induced side effects who were treated with intravenous cyclophosphamide pulse therapy. RESULTS: Out of 18 patients who completed the study, 14 showed good to excellent response. Thirteen were able to decrease their daily dose of steroid to 5-10 mg prednisolone while one could stop steroids altogether. Most patients did not experience serious side effects. DISCUSSION: Thus intravenous pulse cyclophosphamide is a promising form of therapy in pemphigus either recalcitrant or intolerant to steroid therapy. The decreased total cumulative dose of cyclophosphamide with intravenous therapy as compared to oral therapy may reduce the incidence of secondary malignancy.
RESUMO
Late cutaneous syphilis has become a rarity as a result of effective treatment of early and latent syphilis with antibiotics. Superficial nodular lesions of late cutaneous syphilis should be differentiated from conditions including sarcoidosis, leprosy, lupus vulgaris, and granuloma annulare. We report the case of a 50-year-old woman with superficial nodular lesions of late cutaneous syphilis.
Assuntos
Sífilis Cutânea , Sífilis Latente , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Pele/patologia , Sífilis Cutânea/diagnóstico , Sífilis Cutânea/patologia , Sífilis Latente/diagnóstico , Sífilis Latente/patologiaAssuntos
Hipersensibilidade a Drogas/fisiopatologia , Hansenostáticos/efeitos adversos , Hanseníase/tratamento farmacológico , Rifampina/efeitos adversos , Hipersensibilidade a Drogas/etiologia , Humanos , Hansenostáticos/uso terapêutico , Hanseníase/fisiopatologia , Masculino , Pessoa de Meia-Idade , Rifampina/uso terapêuticoRESUMO
Focal dermal hypoplasia is a rare developmental disorder affecting skin, eyes, teeth, and musculoskeletal system. Focal dermal hypoplasia is transmitted as an X-linked dominant disorder but rare male cases occur due to half chromatid mutations. We report on a male child with focal dermal hypoplasia with skin and eye defects. Association of porencephalic cyst in the brain is also reported.
Assuntos
Hipoplasia Dérmica Focal/patologia , Alopecia/patologia , Atrofia , Encefalopatias/patologia , Cicatriz/patologia , Cistos/patologia , Neoplasias Palpebrais/patologia , Humanos , Lactente , Masculino , Papiloma/patologiaRESUMO
Five cases of porokeratosis are reported. Two of these were of the classical mibelli type,in one case only one segment of the limb was involved in a linear fashion, in the fourth case a linear lesion involved the entire left side of the body, and the fifth case was of the disseminated superficial type. Typical histopathological features were observed in porokeratosis of Mibelli and also in the case of disseminated superficial type. In one case short contact dithranol and isotretinoic acid treatment was successful.