Longitudinal neurodevelopmental and neuromotor outcome in congenital diaphragmatic hernia patients in the first 3 years of life.

OBJECTIVE: The objective of this study was to longitudinally evaluate the neurodevelopmental (ND) outcome in congenital diaphragmatic hernia (CDH) survivors during the first 3 years of life. STUDY DESIGN: The study cohort consists of 47 CDH survivors that were enrolled in our prospective, follow-up program between July 2004 and September 2010, and underwent serial ND evaluations during the first 3 years of life. ND outcomes were evaluated using the Bayley Scales of Infant Development (BSID)-II or BSID-III. Persistent ND impairment was defined as a score that remained 79 for the cognitive, language and psychomotor domains at the most recent follow-up visit compared with the first assessment. RESULT: The median age at first and last evaluation was 8 (range, 5 to 15) and 29 (range, 23 to 36) months, respectively. During the follow-up, ND scores improved to average in 17%, remained average in 60%, remained delayed in 10%, improved from severely delayed to mildly delayed in 2% and deteriorated from average to delayed in 15%. Motor scores improved to average in 26%, remained average in 55%, remained delayed in 8% and improved from severely delayed to mildly delayed in 11%. Intrathoracic liver position (P=0.004), preterm delivery (P=0.03), supplemental O2 requirement at day of life 30 (P=0.007), age at discharge (P=0.03), periventricular leukomalacia (PVL; P=0.004) and initial neuromuscular hypotonicity (P=0.01) were associated with persistent motor delays. No relationship was found between patient's characteristics and the risk of persistent cognitive and language delays. CONCLUSION: (1) The majority of children with CDH are functioning in the average range by early preschool age, (2) most children who had early delays showed improvement in their ND outcome, (3) children showing delays in all the three domains were the least likely to show improvement and (4) CDH severity appears to be predictive of persistent psychomotor delays.

Acute mental status changes.

Acute changes in mental status can occur in any hospital setting. Clinicians are often at a loss to define accurately the course of a change in mental status, because of poor differentiation in the terminology surrounding this difficult diagnosis. A clear understanding of the differences among several levels of altered mental status is needed to evaluate, accurately diagnose, and treat those patients with altered mental states. The differential diagnosis of altered mental status is diffuse and includes supratentorial mass lesions, infratentorial mass lesions, and metabolic disorders. Development of an individualized differential diagnosis and diagnostic approach for cases of altered mental status represents a challenge to all levels of clinicians.

Platinum electrode potentials and blood redox balance in the kidney during renal ischemia.

Potentials recorded with a platinum electrode inserted in the cortex and in the medulla of the right kidney "in situ" were compared with the log (Pyruvate)/(Lactate) in the arterial blood and in the blood of the right renal vein, during clamping of the entire pedicle or the renal vein alone. There is no correlation between potentials and log (P)/(L) when the renal blood flow is unimpeded. The medullary potentials correlate with the log (P)/(L) in the renal vein at the time of the removal of the clamp after clamping of the renal vein alone. There is a close correlation between the changes of tissue potentials and the changes of log (P)/(L) in the renal vein between the initial values and values at the time of the removal of the clamp. Thus, it seems possible to estimate by continuous electrical recordings the state and variations of the oxido-reduction balance of a tissue "in vivo".