RESUMO
24 patients with heroin addiction have been observed with the purpose to assess cognitive and neurosis-like disorders during the treatment with Noofen. The methods of research included clinical-psychopathological examination. The course therapy with Noofen reduced intensity of memory and attention disorders and improved general cognitive status of the patients. The therapy with Noofen has not increased a pathological drive to narcotics. Noofen use has improve cognitive sphere alongside with reduction in concomitant psychopathological symptoms including depressive and other disorders.
Assuntos
Transtornos de Ansiedade/prevenção & controle , Dependência de Heroína/tratamento farmacológico , Tranquilizantes/uso terapêutico , Ácido gama-Aminobutírico/análogos & derivados , Adulto , Transtornos de Ansiedade/psicologia , Atenção/efeitos dos fármacos , Cognição/efeitos dos fármacos , Emoções/efeitos dos fármacos , Dependência de Heroína/psicologia , Humanos , Memória/efeitos dos fármacos , Tranquilizantes/administração & dosagem , Resultado do Tratamento , Ácido gama-Aminobutírico/administração & dosagem , Ácido gama-Aminobutírico/uso terapêuticoRESUMO
Statistical analysis of the clinical picture, history data, intraoperative findings and outcomes of treatment in 214 patients with generalized purulent peritonitis provided an algorithm for defining of indications for programmed relaparotomy. The algorithm allowed errors to decrease from 25.2 to 2.4% in the choice of surgical policy for peritonitis and to decrease mortality from 21.0 to 16.7%.
Assuntos
Laparotomia , Peritonite/cirurgia , Algoritmos , Interpretação Estatística de Dados , Humanos , Peritonite/mortalidade , Reoperação , Fatores de TempoRESUMO
Aminohydroxyacetate, an inhibitor of aminotransferases, decreases the rate of oxygen consumption by 1-day-old young rats by 35% 10 min after intraperitoneal injection, whereas for 20-day-old rats, the inhibitory effect is 56%, and for adult mice, it is 83%. More prolonged exposure to aminohydroxyacetate leads to death of the animal. One-day-old rats die 90 min after the injection, 20-day-old rats die 30 min after the injection, and adult mice die 15 min after the injection. Butylmalonate (an inhibitor of mitochondrial dicarboxylate translocator) decreases the rate of energy metabolism to a lower extent, by 38% in adult mice and by 18% in 1-day-old rats. The animals generally remain alive after the exposure to this compound. 1,2,3-benzyltricarboxylate, an inhibitor of tricarboxylate transport, shows only a weak effect on energy metabolism of animals of any age. These results provide evidence that the role of the transaminase system in energy metabolism increases with age. Mechanisms underlying weak sensitivity of newborn animals to these inhibitors are discussed.
