[Morphometric analysis of regression of breast cancer after radiotherapy and thermoradiotherapy]. / Morfometricheskii analiz regressii raka molochnoi zhelezy posle luchevoi i termoluchevoi terapii.

A study was made of 50 infiltrating breast carcinomas, stages II-III, treated with a combined method with or without local UHF-hyperthermia. The object of investigation were cytological and histological specimens, histotopographic tumor slices. Methods of mathematical analysis of correlations between tumor tissue regression and parameters of parenchymal differentiation in cytological specimens and an area of tumor nodes were employed. Tumor tissue regression and differentiation of cell elements in cytological specimens showed correlation in the course of combined treatment on the basis of radiotherapy. Insignificant correlation was revealed between a volumetric density of the tumor parenchyma, preserved after combined treatment with UHF-hyperthermia, and parameters of cell differentiation in cytological specimens. Significantly positive correlation was found between an area of tumor nodes and an area of necrotic foci, developing in them after thermoradiotherapy.

[Clinical x-ray and morphological changes in breast carcinomas during radiothermotherapy]. / Kliniko-rentgenologicheskie i morfologicheskie izmeneniia v kartsinomakh molochnoi zhelezy pri radiotermoterapii.

Clinico-roentgeno-morphological investigation established a marked regression of tumor in as many as 86.1% out of 230 patients with stage IIB and III breast cancer who had undergone radiothermotherapy. Morphologically confirmed complete regression was observed in 12.6% of patients with lesions smaller than 3 cm in diameter at presentation. Treatment was followed by massive necrosis, dystrophic changes and inhibition of mitotic activity of tumor cells in patients with stage III cancer and those with stage IIB who had presented with tumors larger than 3 cm in diameter. However, in all these cases viable tumor cells were still observed at the periphery of tumor.