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1.
Bone Marrow Transplant ; 36(12): 1043-7, 2005 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16247424

RESUMO

Using a reduced-intensity stem cell transplantation (RIST) schedule, 24 patients with Philadelphia (Ph1) (+) chronic myelogenous leukemia (CML) in first chronic phase (CP) were prospectively allografted in four Latin American countries: México, Brazil, Colombia and Venezuela, using HLA-identical siblings as donors. The median age of the patients was 41 years (range 10-71 years); there were eight females. Patients received a median of 4.4 x 10(6)/kg CD34 cells. The median time to achieve above 0.5 x 10(9)/l granulocytes was 12 days, range 0-41 days, and the median time to achieve above 20 x 10(9)/l platelets was also 12 days, range 0-45 days. In all, 22 patients are alive 81-830 (median 497) days after RIST. The 830-day probability of survival is 92%, and the median survival has not been reached, being beyond 830 days. A total of 11 patients (46%) developed acute graft-versus-host disease (GVHD), and seven of 23 (30%) developed chronic GVHD. Two patients died 43 and 210 days after RIST, one as a result of sepsis and the other of chronic GVHD. The 100-day mortality was 4.4%, and transplant-related mortality was 8%. RIST for patients with CML in CP appears to be an adequate therapeutic option.


Assuntos
Antineoplásicos/uso terapêutico , Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico , Leucemia Mielogênica Crônica BCR-ABL Positiva/terapia , Piperazinas/uso terapêutico , Pirimidinas/uso terapêutico , Transplante de Células-Tronco/métodos , Adolescente , Adulto , Idoso , Antígenos CD34/biossíntese , Benzamidas , Remoção de Componentes Sanguíneos , Criança , Feminino , Doença Enxerto-Hospedeiro/terapia , Humanos , Mesilato de Imatinib , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de Tempo , Condicionamento Pré-Transplante , Resultado do Tratamento
2.
Bone Marrow Transplant ; 15(1): 135-6, 1995 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-7742746

RESUMO

We describe a case of cutaneous Nocardia asteroides infection in a 13-year-old Venezuelan boy with aplastic anemia, following allogeneic BMT. He was receiving immunosuppressive therapy with corticosteroids for GVHD and trimethoprim/sulfamethoxazole (TMP/SMX) for prophylaxis against Pneumocystis carinii pneumonia (PCP). He was not neutropenic and gave no history of cutaneous inoculation or trauma. He developed an abscess on the plantar surface of his right big toe from which Nocardia asteroides was isolated. He was successfully treated with a combination of TMP/SMX and minocycline. Despite prolonged immunosuppressive therapy for GVHD, the infection responded and did not recur. TMP/SMX prophylaxis for PCP in BMT recipients with GVHD does not always prevent nocardial infection but may prevent or delay the development of dissemination.


Assuntos
Abscesso/microbiologia , Transplante de Medula Óssea , Hospedeiro Imunocomprometido , Nocardiose/microbiologia , Nocardia asteroides , Dermatopatias Infecciosas/microbiologia , Abscesso/terapia , Adolescente , Anemia Aplástica/terapia , Humanos , Masculino , Nocardiose/terapia , Dermatopatias Infecciosas/terapia
3.
Am J Clin Pathol ; 68(1): 53-6, 1977 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-405860

RESUMO

The incubation of stored blood in a mixture of inosine, pyruvate, glucose, and phosphate restores the O2 affinity of hemoglobin to physiologic levels, as measured by the configuration of the dissociation curve and the P50. This regeneration of normal hemoglobin function not only is consistent for samples anticoagulated with EDTA and stored eight days at 4 C but also is demonstrable for at least 19 days of 4 C storage of EDTA-anticoagulated whole blood. This regeneration procedure is simple to perform and makes it possible to measure reliably O2 affinity in blood samples transmitted by mail.


Assuntos
Preservação de Sangue , Ácido Edético , Hemoglobinas/fisiologia , Ácidos Difosfoglicéricos/sangue , Feminino , Hemoglobinas Anormais , Humanos , Masculino , Oxigênio/sangue , Consumo de Oxigênio
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