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OBJECTIVE: To investigate the influencing factors of hemorrhagic transformation (HT) after mechanical thrombectomy (MT) in patients with large vessel occlusion (LVO) stroke. METHODS: From September 2018 to December 2022, 270 eligible patients with LVO who underwent MT in the First Affiliated Hospital of Nanjing medical University were selected for this retrospective study, and the patients were divided into an occurrence group and a non-occurrence group based on the immediate and 24 h postoperative head CT results. The influencing factors of postoperative HT after MT were identified using univariate and logistic regression analyses. A Nomogram was constructed using logistic variables of significance. Then, area under the ROC curve (AUC) was used to verify the predictive efficacy of the Nomogram, and decision curve analysis (DCA) was used to test the clinical validity of the Nomogram. RESULTS: HT occurred in 60 patients (23.70%) after MT. Logistic regression analysis showed that, male (OR=2.099, 95% CI: 1.051-4.193), age ≥71.5 years (OR=3.780, 95% CI: 1.836-7.782), preoperative NIHSS score ≥16.5 (OR=2.328, 95% CI: 1.112-4.873), operation time ≥58.5 min (OR=2.930, 95% CI: 1.294-6.634), and admission blood glucose ≥7.65 mmol/L (OR=4.915, 95% CI: 2.373-10.178) were risk factors for the occurrence of HT in patients with LVO stroke after MT. Admission serum magnesium ≥0.845 mmol/L (OR=0.225, 95% CI: 0.127-0.513) was a protective factor for the occurrence of HT in the patients after MT. The ROC curve showed that the AUC of the nomogram in the training set and test set were 0.849 (95% CI: 0.787-0.910) and 0.754 (95% CI: 0.634-0.874), respectively. DCA suggested that the nomogram revealed good clinical validity in the training and test sets. CONCLUSION: Sex, age, preoperative NIHSS score, operation time, blood glucose and serum magnesium levels at admission are influencing factors for the occurrence of HT in patients with LVO stroke after MT. The nomogram in this study has a good predictive efficiency, which can improve the diagnostic efficiency of HT after MT in patients with LVO stroke. Therefore, male patients with age ≥71.5 years, preoperative NIHSS score ≥16.5, operation time ≥58.5 min, admission blood glucose ≥7.65 mmol/L, and admission serum magnesium ≤0.845 mmol/L should raise awareness about the risk of HT after MT.
RESUMO
Purpose: To evaluate the prognostic value of the cerebral blood volume (CBV) index for 90-day functional outcomes in patients with acute ischemic stroke (AIS) treated within a late therapeutic window. Methods: We retrospectively reviewed patients who underwent pre-treatment computed tomography perfusion (CTP) and endovascular thrombectomy (EVT) for large-vessel occlusion (LVO) of the anterior circulation within the late therapeutic window between January 2021 and February 2023. Clinical data, the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) based on unenhanced computed tomography (CT), and perfusion parameters, including ischemic core, hypoperfusion volume, mismatch volume between the core and penumbra, and CBV index, were assessed and compared between patients who achieved favorable outcomes (defined as a modified Rankin Scale score of 0-2). Results: Of the 118 patients, 56 (47.5%) had favorable outcomes. In the univariate analysis, age, National Institutes of Health Stroke Scale (NIHSS) score at admission, ASPECTS score, CBV index, and ischemic core volume were significantly associated with functional outcomes (P < 0.05). In multivariate analyses, age (odds ratio [OR], 1.060; 95% confidence interval [CI] 1.013-1.110, P = 0.012), NIHSS score at admission (OR, 1.126; 95% CI 1.031-1.229, P = 0.009), and CBV index (OR, 0.001; 95% CI 0.000-0.240, P = 0.014) were independent predictors of a 90-day favorable outcome. Conclusion: A high CBV index was independently associated with favorable outcomes in patients who underwent mechanical thrombectomy within the late therapeutic window. In addition, a higher CBV index reflects improved blood flow and favorable digital subtraction angiography collateral status.
