Palladium-Catalyzed Arylation of Unactivated γ-Methylene C(sp(3) )-H and δ-C-H Bonds with an Oxazoline-Carboxylate Auxiliary.

A palladium-catalyzed arylation of unactivated γ-methylene C(sp(3) )H and remote δ-CH bonds by using an oxazoline-carboxylate directing group has been developed. Arylation occurs with a broad substrate scope and high tolerance of functional groups (i.e., halogen, nitro, cyano, ether, trifluoromethyl, amine, and ester). The oxazoline-type auxiliary can be removed under acidic conditions.