A new cycloheptane derivative from the fungus Penicillium crustosum JT-8.

A new highly oxygenated cycloheptane derivative crustane (1), along with fourteen known compounds (2-15) were isolated from Penicillium crustosum JT-8. The structure of compound 1 was determined by extensive spectroscopic data, DP4+ probability analyses and dimolybdenum CD method. Compound 1 exhibited moderate antibacterial activity against Staphylococcus aureus with MIC of 4.0 µg/mL.

A new cytotoxic indole alkaloid from the fungus Penicillium polonicum TY12.

A new dimeric monoterpene indole alkaloid polonidine A (1), along with five known compounds, cyclopenol (2), verrucosidin (3), fructigenine A (4), 3-O-methylviridicatin (5) and aurantiomides C (6), were isolated from Penicillium polonicum TY12. Their structures were established on the basis of extensive spectroscopic analyses. Compound 1 exhibited moderate cytotoxic activities and moderate antibacterial activity against Bacillus subtilis with MIC of 4.0 µg/mL.

A new tremulane sesquiterpene from Irpex lacteus by solid-state fermentation.

A new tremulane sesquiterpene, lactedine (1), along with seven known tremulane sesquiterpenes (2-8) and one known triterpene (9) were isolated from the fungus Irpex lacteus. Their structures were established on the basis of extensive spectroscopic data and DP4+ probability analyses.