Analysis of the Effect of Maxillary Expansion Combined with Twin-block Appliances on Malocclusion and Related Factors of Upper Airway Sagittal Diameter Changes.

Objective: To comparatively analyze the therapeutic effect of maxillary expansion combined with twin-block appliances (TBA) versus adenotonsillectomy (ATE) in the treatment of children with upper airway stenosis (UAS) complicated by malocclusion (MA), and to analyze the related factors affecting the changes of the upper airway sagittal diameter. Methods: From October 2020 to October 2022, 54 children with UAS complicated by class II MA were treated at Zhenjiang Stomatological Hospital and Liyang People's Hospital. They were selected as study subjects and were divided as follows a research group (RG) comprised 28 children who received treatment with maxillary expansion combined with TBA and a control group (CG) comprised another 26 children who received ATE. All the children were examined by cone beam computed tomography (CBCT) before and 3 months after treatment. Alterations in upper airway parameters, and changes in the angles of sella-nasion-superior alveolar base point A (

Anti-resonant fiber with high-resistivity silicon for THz wave transmission.

A novel anti-resonant fiber for low-loss terahertz waveguides is proposed and analyzed. The terahertz fiber uses high-resistivity silicon as the bulk material and nine nested double-layer concentric circular tubes in the cladding to reduce propagation losses. The effects of the geometric parameters on the propagation characteristics are analyzed by the finite element method. The result indicates that an ultra-low total loss of 4.9×10-4 d B/m is achieved at f=1T H z. The low-loss propagation window is 0.48 THz ranging from 0.6 to 1.4 THz. In addition, the influence of mechanical bending on the propagation loss is investigated and the bending loss can be maintained at less than 7.3×10-3 d B/m at f=1T H z even if the bending radius is larger than 60 cm. The properties of this anti-resonant fiber are significantly superior to those of previously reported structures and the fiber thus has large commercial potential.

Uncovering an Emerging Group of Halogenated Nucleobase-Derived Disinfection Byproducts in Drinking Water: Prioritization of the Highly Cytotoxic 2-Chloroadenine.

Constant efforts have been devoted to exploring new disinfection byproducts in drinking water causally related to adverse health outcomes. In this study, five halogenated nucleobases were identified as emerging disinfection byproducts in drinking water, including 5-chlorouracil, 6-chlorouracil, 2-chloroadenine, 6-chloroguanine, and 5-bromouracil. We developed a solid phase extraction-ultraperformance liquid chromatography-tandem mass spectrometry method with the limits of detection (LOD) and recoveries ranging between 0.04-0.86 ng/L and 54-93%, respectively. The detection frequency of the five halogenated nucleobases ranged from 73 to 100% with a maximum concentration of up to 65.3 ng/L in the representative drinking water samples. The cytotoxicity of the five identified halogenated nucleobases in Chinese hamster ovary (CHO-K1) cells varied with great disparity, in which the cytotoxicity of 2-chloroadenine (IC50 = 9.4 µM) is appropriately three times higher than emerging DBP 2,6-dichloro-1,4-benzoquinone (IC50 = 42.4 µM), indicating the significant toxicological risk of halogenated nucleobase-DBPs. To the best of our knowledge, this study reports the analytical method, occurrence, and toxicity of halogenated nucleobase-DBPs for the first time. These findings will provide a theoretical basis for further research on probing the relationship between its mutagenicity and human health risk.

Chlorinated nucleotides and analogs as potential disinfection byproducts in drinking water.

Identification of emerging disinfection byproducts (DBPs) of health relevance is important to uncover the health risk of drinking water observed in epidemiology studies. In this study, mutagenic chlorinated nucleotides were proposed as potential DBPs in drinking water, and the formation and transformation pathways of these DBPs in chlorination of nucleotides were carefully investigated. A total of eleven chlorinated nucleotides and analogs were provisionally identified as potential DBPs, such as monochloro uridine/cytidine/adenosine acid and dichloro cytidine acid, and the formation mechanisms involved chlorination, decarbonization, hydrolysis, oxidation and decarboxylation. The active sites of nucleotides that reacted with chlorine were on the aromatic heterocyclic rings of nucleobases, and the carbon among the two nitrogen atoms in the nucleobases tended to be transformed into carboxyl group or be eliminated, further forming ring-opening or reorganization products. Approximately 0.2-4.0 % (mol/mol) of these chlorinated nucleotides and analogs finally decomposed to small-molecule aliphatic DBPs, primarily including haloacetic acids, trichloromethane, and trichloroacetaldehyde. Eight intermediates, particularly chlorinated imino-D-ribose and imino-D-ribose, were tentatively identified in chlorination of uridine. This study provides the first set of preliminary evidence for indicating the promising occurrence of chlorinated nucleotides and analogs as potential toxicological-relevant DBPs after disinfection of drinking water.

Highly sensitive dual-core photonic quasicrystal fiber methane sensor based on surface plasmon resonance.

A highly sensitive dual-core photonic quasicrystal fiber methane sensor based on surface plasmon resonance is designed and analyzed. In this sensor, cryptophane E is doped with polysiloxane and Ag and used as the sensitive film and plasma medium, respectively, for sensitive detection of methane. The influence of the structural parameters on the sensor properties is analyzed by the finite element method. The optimized dual-quasi-D-shape structure has excellent methane-sensing properties such as maximum and average wavelength sensitivities of 14 and 10.98 nm/%, respectively, in the methane concentration range of 0%-3.5%. The sensitivity is better than that of similar sensors reported previously.

Analytical characterization of nucleotides and their concentration variation in drinking water treatment process.

Nucleotides, as the basic building blocks of nucleic acids, widely exist in aqueous environment. In this study, we developed a solid phase extraction-high performance liquid chromatography-tandem mass spectrometry (SPE-UPLC-MS/MS) method for the analysis of 5'-adenosine monophosphate (AMP), 5'-uridine monophosphate (UMP), 5'-cytidine monophosphate (CMP) and 5'-guanosine monophosphate (GMP). The method achieved limits of detection (LODs) of 0.1-1.0 ng/L, and recoveries of 85-95% for the four tested nucleotides. The occurrence and concentrations of the four nucleotides in water from eight representative drinking water treatment and distribution systems in China were determined using this method. All four nucleotides were detectable in water treatment plant (WTP) influent and effluent, at concentrations of up to 30 ng/L and with occurrence frequency of around 90%. The concentrations of identified nucleotides increased 3-10 times after 10 km of water age in the water distribution system. Biological filters and coagulation increased the concentrations of nucleotides, conversely, active carbon, ozonation, and ultrafiltration membrane removed nucleotides in water. The effects of active carbon and coagulation were further confirmed using laboratory-controlled experiment. In addition, monochlorinated nucleotides were identified as the chlorination products of nucleotides.

Improved membrane sequencing batch reactor: effect of carbon and nitrogen volumetric loading rate on dephosphatation.

A lab-scale anaerobic-anoxic-aerobic membrane bioreactor (A2NO-MBR) fed with synthetic wastewater was operated to investigate the impact of influent carbon and nitrogen volumetric loading rate (VLR) on dephosphatation, and the corresponding influent concentration was 100-300 mg L-1 (COD), 24-50 mg L-1 (NH4+-N) and 4.8-6.0 mg L-1 (TP), respectively. The results demonstrated that carbon VLR had a negligible effect on the COD removal with effluent below 50 mg L-1, and high and stable removal capacity for phosphorus were also obtained, regardless of carbon VLR change. Whereas TN removal efficiency was positively correlated with carbon VLR reduction, and lower carbon VLR produced a negative effect on TN removal. In addition, since nitrate served as an electron acceptor for denitrifying phosphorus removal (DPR), a significant effect on nitrogen and phosphorus removal was observed with different nitrogen VLR. The TN and TP removal efficiency was 68.30 ± 1.36%, 70.70 ± 1.23%, 45.19 ± 1.72% and 41.63 ± 3.09%, 98.14 ± 0.53%, 53.34 ± 2.68% with influent nitrogen VLR of 0.024 ± 0.001, 0.034 ± 0.001 and 0.045 ± 0.001 kg-N/(m3 d), respectively. Moreover, bacterial community structure of sludge samples in Run I and V from anaerobic-anoxic-aerobic-SBR (named A2OSBR_1 and A2OSBR_2) and membrane bioreactor (named N-MBR_1 and N-MBR_2) revealed that Candidatus_Accumulibacter was the most dominant genus in A2OSBR_1 (21.50%) and A2OSBR_2 (18.98%). The relative lower carbon VLR favoured the enrichment of Saprospiraceae, which was related with DPR, with the proportion of 9.31% and 14.61% in A2OSBR_1 and A2OSBR_2. Besides, Nitrospira and Nitrosomonas with proportions of 11.14%, 5.38% in N-MBR_1 and 10.72%, 6.77% in N-MBR_2 were observed, which were likely responsible for the nearly complete nitrification.

Performance of A2NO-MBR process in treating synthetic and municipal wastewater.

In this study, a novel anaerobic-anoxic/nitrification (A2N) two-sludge sequencing batch reactor (SBR) configured with post-aeration (A2NO-membrane bioreactor process) was conducted to evaluate the operational efficiency, process characteristics, and microbial community structure in treating synthetic and municipal wastewater. When influent C/N ratios were 4.2-8.6, the removal efficiencies of COD, NH4+-N, TN, and TP were 86.4-90.0, 85.2-93.6, 61.8-76.0, and 97.6-99.3%, respectively, and the effluent concentrations met the first level A criteria of GB18918-2002. Phosphorus removal was mainly in anoxic phase with a removal rate of 0.54-1.30 mgP/(gMLSS h), accounting for 75.9-99.7%. Enhanced phosphorus removal was observed during post-aeration phase with a removal rate of 0.06-0.55 mgP/(gMLSS h). Additionally, Oxidation-Reduction Potential (ORP) and pH could reflect the process of anaerobic phosphorus release and anoxic denitrifying phosphorus removal. DO and pH could indicate the end of nitrification. Moreover, Candidatus Accumulibacter and Dechloromonas related to biological nitrogen and phosphorus removal were enriched effectively with total proportions of 15.9 and 11.5% in treating synthetic and municipal wastewater, respectively.

The summa of fourteen years usage for a medical linear accelerator / 中国医疗器械杂志

This article sum up the fourteen years experience of usage for a linear accelerator in our hospital. The goal is to ensure the secure usage and reduce the damage accidence and attain the rules of quality assurance in radiotherapy by WHO. The ultimate aim is to raise economic benefit and social benefit by linear accelerator.

[Quality assurance for the radiotherapy simulator].

This article expounds the quality assurance for the radiotherapy simulator. Emphasis is given to its necessities and the methods, and standards of regular examinations are illustrated for the aim of meeting the requirements of the quality assurance in radiotherapy by the WHO.

[Quality control and quality assurance for the isocentre of the medical linear accelerator].

This article expounds the method of quality control and quality assurance for the isocenter of the medical linear accelerator and explains the content and standards of its regular examinations, in order to ensure the safety and efficiency in use.

High-quality life extension by the enzyme peptide methionine sulfoxide reductase.

Cumulative oxidative damages to cell constituents are considered to contribute to aging and age-related diseases. The enzyme peptide methionine sulfoxide reductase A (MSRA) catalyzes the repair of oxidized methionine in proteins by reducing methionine sulfoxide back to methionine. However, whether MSRA plays a role in the aging process is poorly understood. Here we report that overexpression of the msrA gene predominantly in the nervous system markedly extends the lifespan of the fruit fly Drosophila. The MSRA transgenic animals are more resistant to paraquat-induced oxidative stress, and the onset of senescence-induced decline in the general activity level and reproductive capacity is delayed markedly. The results suggest that oxidative damage is an important determinant of lifespan, and MSRA may be important in increasing the lifespan in other organisms including humans.