[Hypercalcium crisis and postoperative hungry bone syndrome caused by primary hyperparathyroidism: a case report].

To review the diagnosis and treatment of a case of hypercalcium crisis caused by primary hyperparathyroidism（PHPT） and prophylactic treatment of hungry bone syndrome. In a 32-year-old male with hypercalcemia, the main manifestations were loss of appetite, nausea, polyuria, polydipsia, fatigue, lethargy, etc. parathyroid hormone, serum calcium increased, thyroid function was normal, thyroid color ultrasound and MRI showed space-occupying behind the right thyroid, radionuclide examination showed abnormal imaging agent concentration in the right parathyroid area, there was a history of pathological fracture. Clinically diagnosed as hypercalcemia crisis secondary to PHPT.

Microplastics separation using stainless steel mini-hydrocyclones fabricated with additive manufacturing.

Microplastics have been widely detected in natural and engineered water systems and removing microplastics from various water matrices has become a major challenge. Mini-hydrocyclones (MHCs) have been previously applied to separate mediums of different phases. Given MHCs' capability of separating fine particles from liquid phase, three MHCs were designed and fabricated in stainless steel with 3D printing. Microplastics of densities that were both lower (<1 g·cm-3) and higher (>1 g·cm-3) than water's density were used to test the separation efficiency in ultra-purified water. The separation test was performed on single-stage MHC as well as MHCs in series in a closed hydraulic circuit. A range of important operational parameters, including split ratio, feed pressure, feed flow rate, and solid concentration, were evaluated to optimize the separation efficiency. The single-stage MHC experiment revealed that >80 % microplastics >20 µm can be effectively removed at the concentration tested, and the separation efficiency peaked at the split ratio of 35 %. MHCs in series demonstrated their ability to further enhance the separation efficiency of the ones with the same density, as well as separate microplastics of different densities. Mini-hydrocyclones' were also used to separate microplastics in synthetic stormwater, and separation efficiency reached 84 % and 98.1 % for low-density polyethylene (LDPE) and polyamide (PA). The results indicated the MHCs' potential for large-scale application in microplastic separation for industrial and municipal wastewater.

Abundance, fate, and effects of pharmaceuticals and personal care products in aquatic environments.

Pharmaceuticals and personal care products (PPCPs) are found in wastewater, and thus, the environment. In this study, current knowledge about the occurrence and fate of PPCPs in aquatic systems-including wastewater treatment plants (WWTPs) and natural waters around the world-is critically reviewed to inform the state of the science and highlight existing knowledge gaps. Excretion by humans is the primary route of PPCPs entry into municipal wastewater systems, but significant contributions also occur through emissions from hospitals, PPCPs manufacturers, and agriculture. Abundance of PPCPs in raw wastewater is influenced by several factors, including the population density and demography served by WWTPs, presence of hospitals and drugs manufacturers in the sewershed, disease burden of the population served, local regulations, and climatic conditions. Based on the data obtained from WWTPs, analgesics, antibiotics, and stimulants (e.g., caffeine) are the most abundant PPCPs in raw wastewater. In conventional WWTPs, most removal of PPCPs occurs during secondary treatment, and overall removal exceeds 90% for treatable PPCPs. Regardless, the total PPCP mass discharged with effluent by an average WWTP into receiving waters (7.35-20,160 g/day) is still considerable, because potential adverse effects of some PPCPs (such as ibuprofen) on aquatic organisms occur within measured concentrations found in surface waters.

A composite indicator approach to assess the sustainability and resilience of wastewater management alternatives.

Evaluating the sustainability of wastewater management alternatives is a challenging task. This paper proposes an innovative methodology to assess and compare the sustainability of four wastewater management alternatives: a) centralised water resource recovery facility (WRRF) based on activated sludge (AS); b) centralised WRRF with membrane bioreactors (MBR); c) decentralised WRRFs with upflow anaerobic sludge blanket reactors and trickling filters; d) centralised-decentralised hybrid system. In doing so, a composite indicator embracing total annual equivalent costs, carbon emission intensity, eutrophication and resilience (based on robustness and rapidity metrics) was developed using the analytic hierarchy process (AHP) method. The results show that decentralised and hybrid systems contribute less to carbon emission and eutrophication because of energy and fertilizer harvest and with a trade-off of higher costs of 7-17% than the ones of AS and MBR. In addition, decentralised and hybrid systems are more resilient, contributing to lower environmental impacts facing natural disasters. Based on the weights obtained by AHP, the decentralised alternative appears to be the most sustainable option due to its best performance in terms of carbon emission intensity and resilience. By contrast, the MBR alternative appeared the least sustainable evaluated wastewater management alternative. However, this alternative is sustainable option when the eutrophication criterion is heavily prioritized. The proposed approach contributes to the selection of the most sustainable wastewater management alternative from a holistic perspective.

[Clinical research on relationship between angiogensis and TCM syndrome type of cyclomastopathy].

OBJECTIVE: To study the relationship between angiogensis and TCM Syndrome type of cyclomastopathy (CMP) to investigate the objective standardization of TCM Syndrome diagnosis of the disease. METHODS: One hundred and forty patients with CMP were divided into three groups according to TCM syndrome typing. The pathological type, grade and expressions of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and microvascular density (MVD) in mammary biopsy were observed. RESULTS: The expressions of VEGF, bFGF and MVD was different in CMP patients of different TCM types and pathological grades (P < 0.05). The proportion of atypical proliferation, the count of MVD and the expression of VEGF and bFGF were higher in patients of phlegm and stasis type than those in Gan stagnation caused Qistagnation type and Chong and Ren meridians disorder type. CONCLUSION: TCM Syndrome type of CMP patients is related with vascular activity and grade of angiogensis. The pathological characteristics of mammary tissue and expression of VEGF, bFGF and MVD can be regarded as the objective indexes of TCM typing and clinical efficacy evaluation for CMP.

The Drosophila Egg Chamber: External Ionic Currents and the Hypothesis of Electrophoretic Transport.

In insect egg chambers the nurse cells produce cytoplasm which is transported into the oocyte. It has been proposed that the transport is driven by an electrophoretic current resulting from a voltage gradient produced by the egg chamber. There are contradictory reports concerning the existence of significant voltage gradients. Any internal current must have a return pathway. An extracellular current surrounding the egg chamber that is in the opposite direction to that required for the return of an electrophoretic current has been reported, but other authors have not found such a consistent current. We used the vibrating probe to measure the extracellular currents surrounding 50 egg chambers during the stage of maximum transport. Our set of measurements was predominantly characterized by small and variable currents. Most of the measurements were on the order of 1 microampere/cm2, and no particular pattern of current flow was consistently evident. Although it was possible to pick out some egg chambers that appeared to show patterns of current flow, approximately equal numbers of egg chambers showed patterns of opposite types, and most showed no pattern at all. Our data do not support the presence of a consistent pattern of ionic current.