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1.
Chin J Nat Med ; 17(7): 545-550, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31514986

RESUMO

Two new flavonoid glycosides, named viscumneoside XII (1), and viscumneoside XIII (2); a new dihydrogen flavonoid glycoside product named viscumneoside XIV (3), were isolated from the aerial part of Viscum album, along with seven known compounds (4-10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory activities against C6, A549 and MDA-MB-231 (the inhibition rate arrived about 50%, 70% and 74% respectively with IC50 ≤ 60.00 µmol·L-1), while the inhibition of TF-1 and Hela was not significant.


Assuntos
Antineoplásicos/química , Flavonoides/química , Glicosídeos/química , Viscum album/química , Antineoplásicos/farmacologia , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Flavonoides/farmacologia , Glicosídeos/farmacologia , Humanos , Estrutura Molecular , Componentes Aéreos da Planta/química , Extratos Vegetais/química , Extratos Vegetais/farmacologia
2.
Chin J Nat Med ; 17(2): 145-148, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30797420

RESUMO

In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 - 11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activity against xanthine oxidase (XOD) and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydroxyl (DPPH), with the IC50 of 1.22 and 1.33 µmol·L-1, and the SC50 of 4.34 and 8.22 µmol·L-1, respectively.


Assuntos
Antioxidantes/química , Viscum album/química , Acetileno/química , Antioxidantes/farmacologia , Compostos de Bifenilo/química , Estrutura Molecular , Picratos/química , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Folhas de Planta/química , Xantina Oxidase/química
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