Magneto-acousto-electrical tomography using nonlinearly frequency-modulated ultrasound.

Objective. In this study, nonlinearly frequency-modulated (NLFM) ultrasound was applied to magneto-acousto-electrical tomography (MAET) to increase the dynamic range of detection.Approach. Generation of NLFM signals using window function method-based on the principle of stationary phase-and piecewise linear frequency modulation method-based on the genetic algorithm-was discussed. The MAET experiment systems using spike, linearly frequency-modulated (LFM), or NLFM pulse stimulation were constructed, and three groups of MAET experiments on saline agar phantom samples were carried out to verify the performance-respectively the sensitivity, the dynamic range, and the longitudinal resolution of detection-of MAET using NLFM ultrasound in comparison to that using LFM ultrasound. Based on the above experiments, a pork sample was imaged by ultrasound imaging method, spike MAET method, LFM MAET method, and NLFM MAET method, to compare the imaging accuracy.Main results. The experiment results showed that, through sacrificing very little main-lobe width of pulse compression or equivalently the longitudinal resolution, the MAET using NLFM ultrasound achieved higher signal-to-interference ratio (and therefore higher detection sensitivity), lower side-lobe levels of pulse compression (and therefore larger dynamic range of detection), and large anti-interference capability, compared to the MAET using LFM ultrasound.Significance. The applicability of the MAET using NLFM ultrasound was proved in circumferences where sensitivity and dynamic range of detection were mostly important and slightly lower longitudinal resolution of detection was acceptable. The study furthered the scheme of using coded ultrasound excitation toward the clinical application of MAET.

Shear Wave Generation by Remotely Stimulating Aluminum Patches With a Transient Magnetic Field and Its Preliminary Application in Elastography.

OBJECTIVE: This article presents shear wave generation by remotely stimulating aluminum patches through a transient magnetic field, and its preliminary application in the cross-correlation approach based ultrasound elastography. METHODS: A transient magnetic field is employed to remotely vibrate the patch actuators through the Lorentz force. The origin, and the characteristics of the Lorentz force are confirmed using an interferometric laser probe. The shear wave displacement fields generated in the soft medium are studied through the ultrafast ultrasound imaging. The potential of the shear wave fields generated through the patch actuators for the cross-correlation approach based elastography is confirmed through experiments on an agar phantom sample. RESULTS: Under a transient magnetic field of changing rate of 10.44 kT/s, the patch actuator generates a shear wave source of amplitude of 100  µm in a polyvinyl alcohol (PVA) phantom sample. The shear wave fields created by experiments agree qualitatively well with those by theory. From the shear wave velocity map computed from 100 frames of shear wave fields, the boundaries of cylindrical regions of different stiffness can be clearly recognized, which are completely concealed in the ultrasound image. CONCLUSION: Shear wave fields in the level of 100  µm can be remotely generated in soft medium through stimulating aluminum patches with a transient magnetic field, and qualitative shear wave velocity maps can be reconstructed from the shear wave fields generated. SIGNIFICANCE: The proposed method allows potential application of the cross-correlation approach based elastography in intravascular-based or catheter-based cardiology.

Lorentz Force Electrical-Impedance Tomography Using Linearly Frequency-Modulated Ultrasound Pulse.

Lorentz force electrical-impedance tomography (LFEIT) combines ultrasound stimulation and electromagnetic field detection with the goal of creating a high-contrast and high-resolution hybrid imaging modality. To reduce the peak stimulation power to the ultrasound transducer in LFEIT, linearly frequency-modulated (LFM) ultrasound pulse was investigated in this paper. First, the coherency between LFM ultrasound excitation and the resulting local current density was established theoretically. Then, experiments were done using different agar phantoms of conductivity ranging from 0.2 to 0.5 S/m. The results showed: 1) using electrical signal of peak instantaneous power of 39.54 dBm to the ultrasound transducer, which was 25.5 dB lower than the peak instantaneous power of the high-voltage narrow pulse adopted in traditional LFEIT (65.05 dBm), the LFM ultrasound pulse-based LFEIT can detect the electrical conductivity discontinuity positions precisely; 2) the reconstructed B-scan image of the electrical conductivity discontinuity distribution is comparable to that obtained through LFEIT with high-voltage narrow pulse; and 3) axial resolution of 1 mm was achieved with the experimental setup. The method of LFM ultrasound pulse stimulation and coherent detection initiates an alternative scheme toward the clinical application of LFEIT.

Effect of the secondary process on mass point vibration velocity propagation in magneto-acoustic tomography and magneto-acousto-electrical tomography.

BACKGROUND: As two of the new biological electrical impedance tomography (EIT), magneto-acoustic tomography (MAT) and magneto-acousto-electrical tomography (MAET) achieve both the high contrast property of EIT and the high spatial resolution property of sonography through combining EIT and sonography. As both MAT and MAET contain a uniform magnetic field, vibration and electrical current density, there is a secondary process both in MAT and in MAET, which is MAET and MAT respectively. OBJECTIVE: To analyze the effect of the secondary process on mass point vibration velocity (MPVV) propagation in MAT and MAET. METHODS: By analyzing the total force to the sample, the wave equations of MPVV in MAT and MAET - when the secondary processes were considered - were derived. The expression of the attenuation constant in the wave number was derived in the case that the mass point vibration velocity propagates in the form of cylindrical wave and plane wave. Attenuations of propagation of the MPVV in several samples were quantified. RESULTS: Attenuations of the MPVV after propagating for 1 mm in copper or aluminum foil, and for 5 cm in gel phantom or biological soft tissue were less than 1%. CONCLUSION: Attenuations of the MPVV in MAT and MAET due to the secondary processes are relatively minor, and effects of the secondary processes on MPVV propagation in MAT and MAET can be ignored.