RESUMO
In 2 cases of squamous cell carcinoma of maxillary gingiva, carboplatin (CBDCA) was administered by continuous infusion for 5 days, and the clinical outcome and platinum concentrations in the peripheral blood, urine and tissue were investigated. Clinical effects were PR in one of the 2 cases and CR in the other. Platinum concentrations were as high as 3.17 and 13.90 micrograms/g in the tissue, but low in peripheral blood, not exceeding 0.61 and 0.62 micrograms/ml, respectively. These findings suggested that the present method secures the transport of the agent to a local site, with possible reduction of side effects.
Assuntos
Carboplatina/administração & dosagem , Carcinoma de Células Escamosas/tratamento farmacológico , Neoplasias Gengivais/tratamento farmacológico , Idoso , Carboplatina/farmacocinética , Carcinoma de Células Escamosas/metabolismo , Feminino , Neoplasias Gengivais/metabolismo , Humanos , Infusões Intra-Arteriais , Masculino , Maxila , Platina/análiseRESUMO
Plummer-Vinson syndrome has been brought to attention as a precancerous lesion of hypopharyngeal and cervical lesions of the esophagus, but that involving the stomach is uncommon. We report a case of Plummer-Vinson syndrome with gastric cancer. A brief literature review of this disorder is presented, and possible causes in this unusual case are discussed.
