RESUMO
On the third day after a single administration of nitrosodimethylamine (30 mg/kg) to white rats histochemistry reveals the greatest injury to the liver parenchyma. This correlates with a reduction in relative strength of intercellular contacts, an increase in relative strength of the membranes, and an elevation of the membrane potential during liver tissue survival in vitro. The latter fact can be explained, at any rate partially, by the lowering of the activity of cytoplasmic ATPase which competes with electrogenic Na+. K+-ATPase for ATP.
Assuntos
Dimetilnitrosamina/toxicidade , Fígado/efeitos dos fármacos , Animais , Fenômenos Biofísicos , Biofísica , Membrana Celular/efeitos dos fármacos , Junções Intercelulares/efeitos dos fármacos , Fígado/citologia , Fígado/enzimologia , Masculino , Potenciais da Membrana/efeitos dos fármacos , Ratos , Fatores de TempoRESUMO
Under the influence of atmospheric pollutions certain structural-functional changes take place in placenta: terminal villi per stipulated square unite, villi with desquamated epithelium, with dilated vessels, with deposition of fibrinoid masses, with plasmodial buds increase in number; section area occupied by epithelial layer decreases; RNA concentration and histoenzymatic activity change in the latter.