RESUMO
Governments and health officials are eager to gain a thorough understanding of the dynamics of COVID-19 transmission in order to devise strategies to mitigate the pandemic's negative effects. As a result, we created a new fractional order mathematical model to investigate the dynamics of Covid-19 vaccine transmission in Ethiopia. The nonlinear system of differential equations for the model is represented using Atangana-Baleanu fractional derivative in Caputo sense and the Jacobi spectral collocation method is used to convert this system into an algebraic system of equations, which is then solved using inexact Newton's method. The fundamental reproduction number, R 0 for the proposed model is determined using the next generation matrix approach.
RESUMO
alpha-Alkoxy arylpropanoic acids containing 2-phenyloxazole-4yl-alkyl moiety are found to be potent hypolipidemic agents. These compounds were potent activators of the peroxisome proliferator activated receptor gamma (PPARgamma), with moderate PPARalpha activity and known to cause adverse effects such as weight gain and edema, which are essentially attributed to PPARgamma activation. Although extensive work has been done on the phenylpropanoic acid class of compounds, other phenyl propane derivatives such as alcohols, amines, ethers etc. have not received much attention. In order to develop predominant PPARalpha agonists as hypolipidemic agents with minor chemical modifications on compound III, we have synthesised few (2S)-ethoxyphenylpropane derivatives containing a 2-phenyl-5-methyloxazole-4ylalkoxy moiety of the general formula IV and evaluated by PPARalpha and gamma transactivation assay in conjugation with in vivo studies in male Swiss albino mice model. Compounds 3c and 3d showed the desired predominant PPARalpha activity and excellent tryiglyceride reduction in vivo and were selected as lead compounds for further development as hypolipidemic agents.
