[Electroencephalography monitoring at total and managed hyperthermia to 44 degrees C]. / Elektroéntsefalograficheskii monitoring pri obshchei upravliaemoi gipertermii do 44 gradusov C

In 34 patients the abstinence syndrome was treated by hypothermia (HT) with the EEG monitoring. HT was carried out under the general propofol-fentanil anesthesia. HT was achieved in the "Hirana" bath. The temperature was increased gradually by 1 degree C per 5 minutes up to 44 degrees C. EEG was recorded before anesthesia, as well as during and after the procedure. On the initial EEG alpha- and beta-rhythms were predominant. Under the anesthesia both alpha-rhythm frequency and amplitude were enhanced, spikes and wave discharges appeared. Under HT (t = 40-42 degrees C) low voltage and wave slowing were recorded. In the range t degree--42.5-43.4 degrees C EEG registered the appearance of clinically significant "biological break point", which was followed by neuropeptide destruction. At t degree--43-44 degrees C acute suppression and, then, electrocerebral silence were observed in a majority of patients. At the end of the procedure (t = 39 degrees C) EEG returned to the initial recording.

[Pathogenetic treatment of acute pancreatitis]. / O patogeneticheskom lechenii ostrogo pankreatita.

In acute experiments in albino rats it was shown that mannitol, polyglucin and hemodesis possess antiproteolytic properties. Pyridoxine, hemodesis and polyglucin were also found to be antagonists to the effects of bradykinin. Pyridoxine, polyglucin and hemodesis proved to be most effective in the treatment of experimental trypsinemia. The results of the conservative treatment of patients with acute pancreatitis were better if pyridoxine and polyglucin were added to the complex of curative measures.