Modified STING procedure for high-grade vesicoureteral reflux in children: intraureteral injection with ureteral orifice reposition technique.

We describe a modified endoscopic injection technique for the treatment of vesicoureteral reflux (VUR). Our modification combines the STING and proximal HIT injection techniques and results in higher success rates in the resolution in VUR.

Placental insufficiency in early gestation is associated with hypospadias.

BACKGROUND AND PURPOSE: The association of growth retardation and hypospadias is well established. Fetal testosterone secretion is under the influence of placental human chorionic gonadotropin during first 14 weeks of gestation. We hypothesized that placental insufficiency may disrupt the supply of nutrients and human chorionic gonadotropin to the fetus leading to both growth retardation and hypospadias. To validate this hypothesis, we analyzed extremely low-birth-weight male infants with or without hypospadias for fetal growth parameters. MATERIALS AND METHODS: One hundred four male newborn infants with birth body weight of less than 1500 g admitted to a neonatal intensive care unit over a 4-year period were retrospectively reviewed, recording the presence and type of hypospadias, fetal growth parameters, infant growth parameters at birth, placental weight, placental histopathology, cord information, and maternal morbidity. These data of patients with hypospadias were compared with those of controls. RESULTS: Of the 104 extremely to very low-birth-weight male infants, 16 (15.3%) had hypospadias, and 10 (62.5%) of those had severe proximal hypospadias. Sixty-two controls who did not have hypospadias and whose body weight was less than 1500 g were identified. The incidence of hypospadias in full-term male birth in the hospital was 12 (0.30%) in 3959 births. Birth body weight and their SD for gestational age were lower in patients with hypospadias compared with those for controls (824 +/- 160 vs 1255 +/- 145 g). Placenta-to-fetal ratio (0.323 +/- 0.07 vs 0.229 +/- 0.03) and gestational age were significantly higher in the patients with hypospadias. Histopathologic study of the maternal placenta obtained from the patients with hypospadias revealed pronounced degenerative changes, infarction, and calcification, whereas these abnormalities were rare in controls. CONCLUSIONS: The significant association between the occurrence of hypospadias and early growth retardation with higher placenta-to-fetal ratio and placental abnormalities suggest that placental dysfunction in early gestation may play an important role in the development of hypospadias.

Paraurethral cyst in female newborn: is surgery always advocated?

AIM OF THE STUDY: Paraurethral cysts in females are rare, particularly in the neonatal period. Only 49 cases have been previously reported in English literature. The choice of management for this lesion remains controversial. Surgical management has been advocated, but spontaneous regression has also been reported. The aim of the study was to clarify the natural course of paraurethral cysts in female neonates and discuss the proper choice of treatment. PATIENTS AND METHODS: Neonates who presented to our surgical unit with paraurethral cyst over a 5-year period (January 2000 through December 2005) were studied. The "nonoperative strategy" was indicated, and their clinical course and outcomes were examined. RESULTS: Five consecutive patients with paraurethral cysts in female neonates were treated. There have been 5192 female births during the same period, and the incidence of paraurethral cyst was 1 in 1038 female births. None was associated with other anomalies. Clinical examination revealed interlabial cystic mass, which is spherical and yellowish in color, with dilated blood vessel on the anterior surface. It obscured both urethral meatus and vaginal orifice. However, there was no apparent voiding difficulty. These paraurethral cysts spontaneously disappeared at follow-up 76 to 304 days after birth. CONCLUSION: Our data suggest that the number of reported case, being fewer than predicted, suggests that paraurethral cysts in female neonates are unrecognized. Paraurethral cysts are generally characterized by a completely asymptomatic lesion and have a high rate of spontaneously resolution. Thus, surgery (aspiration, marsupialization, or excision) should not be hurried, because natural resolution within a few months is the likely outcome.