Neural changes with attention bias modification for anxiety: a randomized trial.

Attention bias modification (ABM) procedures typically reduce anxiety symptoms, yet little is known about the neural changes associated with this behavioral treatment. Healthy adults with high social anxiety symptoms (n = 53) were randomized to receive either active or placebo ABM. Unlike placebo ABM, active ABM aimed to train individuals' attention away from threat. Using the dot-probe task, threat-related attention bias was measured during magnetic resonance imaging before and after acute and extended training over 4 weeks. A subset of participants completed all procedures (n = 30, 15 per group). Group differences in neural activation were identified using standard analyses. Linear regression tested predictive factors of symptom reduction (i.e., training group, baseline indices of threat bias). The active and placebo groups exhibited different patterns of right and left amygdala activation with training. Across all participants irrespective of group, individuals with greater left amygdala activation in the threat-bias contrast prior to training exhibited greater symptom reduction. After accounting for baseline amygdala activation, greater symptom reduction was associated with assignment to the active training group. Greater left amygdala activation at baseline predicted reductions in social anxiety symptoms following ABM. Further research is needed to clarify brain-behavior mechanisms associated with ABM training.

The relations among theory of mind, behavioral inhibition, and peer interactions in early childhood.

The current study examined relations among child temperament, peer interaction, and theory of mind (ToM) development. We hypothesized that 1) children classified as behaviorally inhibited at 24 months would show less ToM understanding at 36 months in comparison to non-behaviorally inhibited children, 2) children who displayed negative peer interaction behaviors in a peer dyadic interaction at 24 months would exhibit less ToM understanding at 36 months, and 3) Behavioral inhibition (BI) and the degree of negative behaviors during a peer interaction would jointly influence ToM development, such that children with both heightened BI and negative peer interaction behaviors would exhibit worse ToM performance than behaviorally inhibited children who did not display negative social behaviors. Both BI and negative peer interaction behaviors were associated with passing fewer ToM tasks. The data revealed that children high in both BI and negative peer interaction behaviors passed fewer ToM tasks at 36 months of age than those high in BI and low in negative peer interactions or those low in BI.

Cascading effects: the influence of attention bias to threat on the interpretation of ambiguous information.

Both attention bias to threat and negative interpretive bias have been implicated in the emergence and maintenance of anxiety disorders. However, relations between attention and interpretive biases remain poorly understood. The current study experimentally manipulated attention bias to threat and examined the effects of attention training on the way ambiguous information was interpreted. Results suggest that the preferential allocation of attention towards threat affects the manner in which ambiguous information is interpreted. Individuals trained to attend to threat were more likely than individuals in a placebo training group to interpret ambiguous information in a threat-related manner. These data suggest that perturbations in the initial stages of information processing associated with anxiety may lead to a cascade of subsequent processing biases.