[The adaptational properties and immunoregulatory action of a preparation of proteolytic enzymes in experimental stress]. / Adaptatsionnye svoistva i immunoreguliatornoe deistvie preparata proteoliticheskikh fermentov pri éksperimental'nom stresse.

The use of the experimental model of the development of acute secondary immunodeficiency, accompanied by the redistribution of immunoglobulins from plasma to blood cells, for evaluating the effect of immunomodulation is substantiated. The preparation of proteolytic enzymes Wobenzym [correction of "Vobenzyme"] has been shown to produce significant and dose-dependent decrease the sorption of immunoglobulins on mouse cells in the process of swimming.

[Automated calculation of the RD parameter in euglycemic insulinemic clamp]. / Avtomatizirovannyi raschet parametra RD v éuglikemicheskom insulinemicheskom klémpe.

The authors proposed a new analytical approach to a search for the RD parameter in euglycemic insulinemic clamp which imparts a rate to glucose infusion. Two diabetic patients were investigated (RD parameter in the first case was determined by intuition, and in the second case--on the basis of mathematical iterative formulas). The analytical approach permitted a two-fold reduction of the time of clamp investigation improving its quality.

[Reserve potentials of immunity]. / Rezervnye vozmozhnosti immuniteta.

The immunological examination of 350 top level sportsmen has been made at different stages of training and competitions. This examination has revealed that the reaction of the immune system to superextreme loading can be divided into 4 phases: activation, compensation, decompensation and restoration. In the process of adaptation to increasing muscular loading, characteristic of modern competitive sport, the reserves of the immune system are mobilized, and the immunological characteristics are thus maintained at the initial level. In some of healthy adults the action of superextreme physical and psychoemotional loading produces the exhaustion of immunity reserves, which is manifested by the disappearance of certain classes of immunoglobulin from the blood and biological secretions 1-2 hours after the cessation of this action.

[The phenomenon of the formation of universal rosette-forming cells under superextreme loads]. / Fenomenon obrazovaniia universal'nykh rozetkoobrazuiushchikh kletok pri superékstremal'nykh nagruzkakh.

A combined immunological study of cell-mediated and humoral immunity factors in sportsmen at the period of important competitions was made. The effect of the maximum bearable load was found to lead to the formation of a great number of universal rosette-forming lymphocytes and neutrophils. In the control group their number did not exceed 1-4% of the total population of these cells. Simultaneously, the suppression of the phagocytic activity of neutrophils and some of the humoral factors of systemic and local immunity with the parallel development of compensating processes were recorded.

[Neutrophil phagocytic activity and the humoral factors of general and local immunity under intensive physical loading]. / Fagotsitarnaia aktivnost' neitrofilov i gumoral'nye faktory obshchego i mestnogo immuniteta pri intensivnykh fizicheskikh nagruzkakh.

The comparative examination of 91 sportsmen under physical strain of different intensity and 30 healthy adults not active in sport has been made. A decrease in the functional activity of neutrophils in response to increasing physical strain has been revealed, which coincides with a drop in the levels of normal serum and secretory antibodies, immunoglobulins and lysozyme.