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1.
Biomaterials ; 25(20): 4929-34, 2004 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-15109853

RESUMO

Implant surface roughness is an important parameter governing the overall mechanical properties at the implant-cement interface. This study investigated the influence of surface roughness using polymethylmethcrylate (PMMA) and a Bisphenol-a-glycidylmethacyrlate resin-hydroxyapatite cement (CAP). Mechanical fixation at the implant-cement interface was evaluated in vitro using static shear and fatigue loading with cobalt chrome alloy (CoCr) dowels with different surface roughness preparations. Increasing surface roughness improved the mechanical properties at the implant-cement interface for both types of cement. CAP cement fixation was superior to PMMA under static and dynamic loading.


Assuntos
Materiais Biocompatíveis , Bis-Fenol A-Glicidil Metacrilato/química , Cimentos Ósseos/química , Durapatita/química , Polimetil Metacrilato/química , Ligas , Cimentação , Ligas de Cromo/química , Cobalto/química , Cimentos de Ionômeros de Vidro/química , Temperatura Alta , Microscopia de Força Atômica , Microscopia Eletrônica de Varredura , Próteses e Implantes , Estresse Mecânico , Propriedades de Superfície
2.
J Orthop Res ; 21(4): 655-61, 2003 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12798065

RESUMO

The success of converted corals as a bone graft substitute relies on a complex sequence of events of vascular ingrowth, differentiation of osteoprogenitor cells, bone remodeling and graft resorption occurring together with host bone ingrowth into and onto the porous coralline microstructure or voids left behind during resorption. This study examined the resorption rates and bone infiltration into a family of resorbable porous ceramic placed bilaterally in critical sized defects in the tibial metaphyseal-diaphyseal of rabbits. The ceramics are made resorbable by partially converting the calcium carbonate of corals to form a hydroxyapatite (HA) layer on all surfaces. Attempts have been made to control the resorption rate of the implant by varying the HA thickness. New bone was observed at the periosteal and endosteal cortices, which flowed into the centre of the defect supporting the osteoconductive nature of partially converted corals. The combination of an HA layer and calcium carbonate core provides a composite bone graft substitute for new tissue integration. The HA-calcium carbonate composite demonstrated an initial resorption of the inner calcium carbonate phase but the overall implant resorption and bone ingrowth behaviour did not differ with HA thickness.


Assuntos
Substitutos Ósseos/farmacologia , Cerâmica , Durapatita/farmacologia , Osseointegração/efeitos dos fármacos , Tíbia/cirurgia , Animais , Antozoários/ultraestrutura , Reabsorção Óssea/tratamento farmacológico , Carbonato de Cálcio/farmacocinética , Fosfatos de Cálcio/metabolismo , Diáfises/fisiologia , Diáfises/cirurgia , Microscopia Eletrônica de Varredura , Modelos Animais , Coelhos , Tíbia/fisiologia , Anormalidade Torcional , Suporte de Carga
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