[The influence of vitamins A, E, C upon the respiration activity of the spleen lymphocytes ].

In the experiment on albino male mongrel rats some parameters of oxidative phosphorylation of spleen slices were studied after the animals were fed the antioxidant complex of vitamins E, A, and C. The stimulation of oxygen consumption rate and of tissue respiration of spleen was observed with endogenous substrates, and after exogenous substrates (succinate and glutamate) were added. After the ingestion of vegetable oil the uncoupling of oxidative phosphorylation was observed. The perspectives of alimentary and medicine immunocorrection by the influence upon the mitochondrial oxidation system of cell immune competence organ discussed.

[Characteristics of mitochondria and myocardium ultrastructure of rats following chronic incorporation of cesium radionuclides 137 Cs]. / Kharakteristika mitokhondrii i ul'trastruktura miokarda krys v usloviiakh prodolzhitel'noi inkorporatsii radionuklidov 137 Cs.

Ultrastructure, tissue respiration and oxidative phosphorilation were studies in the myocardium of animals after chronic natural irradiation by 137Cs in quantities that can in reality threaten population of radionuclide-polluted regions. Decline in the respiratory activity of the myocardium and ultrastructural disorders can be attributed to the effects of ions of radioactive Cs which is also a potassium antagonist. A hypothesis has been put forward according to which cesium blocks potassium channels in mitochondria and thus changes the volume and configuration of internal mitochondrial membranes, and impacts the respiratory processes. In the opinion of the authors, these changes characterize the mitochondrial phase of apoptosis which, in the event of chronic exposure to radionuclides, is a compensatory-adaptive mechanism eliminating the least immutable subpopulation of cardiomyocites.

[Mitochondrial oxidation and ultrastructure of the myocardium on a background of incorporation of cesium radionuclides]. / Mitokhondrial'noe okislenie i ul'trastruktura miokarda pri inkorporatsii radionuklidov tseziia.

Parameters of the mitochondrial oxidation and ultrastructure of the myocardium in white rats were studied on a background of consumption of food supplemented with 137Cs at 60 or 600 Bq/kg (calculated doses were 1.5 and 15 microGy, respectively). The observed stimulation of the respiratory activity in myocardial samples cultivated on endogenous and several exogenous substrates was found to reduce the effectiveness of energy production by dissociation of oxidative phosphorylation and disruption of macroerg deposition in the form of creatine phosphate. Ultrastructural findings included swelling of mitochondria, matrix clarification, partial reduction of the number of crists, and myeline-like bodies in the matrix. Observed were high nucleus structural polymorphism with extension of the perinuclear space, spotted distribution of chromatin, and modification of the myofibril structure. These morphofunctional changes can be considered as reflection of apoptosis associated with activation of peroxidation.

[Effect of the synestrol analog sigetin on serum lipid levels of lipoprotein lipid composition in rabbits]. / Deistvie analoga sinestrola sigetina na uroven' lipidov i na lipidnyi sostav lipoproteidov syvorotki krovi krolikov.

Analogue of hexestrol sigethine, deprived of the estrogenic effect, was shown to decrease the content of cholesterol in blood serum, liver tissue and aorta, as well as to reduce the fraction of very low density lipoproteins and content of cholesterol in this fraction of hyperlipidemic rabbits. Diethylstilbestrol lowered the content of cholesterol in blood serum of intact rabbits. Simultaneous administration of diethylstilbestrol and sigethine decreased the concentration of triglycerides in blood serum, increased the fraction of alpha-lipoproteins and of cholesterol in the serum.

[Effect of sigetin on the concentration of triglycerides and cholesterol in rat blood and liver]. / Vliianie sigetina na soderzhanie triglitseridov i kholesterina v krovi i pecheni krys.

It was shown in experiments on male rats that sygethin an analogue of synesterol devoid of estrogenic effect decreased cholesterol level in the intact animals and diminished hypercholesterolemia induced by dexamethasone. Sygethin inhibited the hypertriglyceridemia induced by diethylstilbestrol, as well as by ethanol and dexamethasone.