RESUMO
Intravenous injection of 1 microg/kg desmopressin to rabbits not only accelerated clotting of arterial blood (maximally by 59.16 +/- 8.53% after 1 h), but also increased the number of microvesicles containing the integral enzyme 5'-nucleotidase in the arterial blood from the initial level of 36.26 +/- 8.08 ncat/liter to a maximum of 99.65 +/- 15.8 ncat/liter after 15 min.
Assuntos
Desamino Arginina Vasopressina/farmacologia , Hemostasia/efeitos dos fármacos , 5'-Nucleotidase/sangue , Animais , Coagulação Sanguínea/efeitos dos fármacos , Fator VIII/metabolismo , Hemostasia/fisiologia , Coelhos , Ativador de Plasminogênio Tecidual/sangue , Corpos de Weibel-Palade/efeitos dos fármacos , Corpos de Weibel-Palade/metabolismo , Fator de von Willebrand/metabolismoRESUMO
The dynamics of microvesicle formation in arterial blood in generalized Schwartzman phenomenon was studied. Successive (with 24-h interval) intravenous injections of endotoxin to rabbits in a dose of 1 mg/kg and 3 mg/kg caused an increase in the content of microvesicles in the blood, some of them containing ecto-5'-nucleotidase. Biphasic changes in arterial blood clotting time and erythrocyte hemolysis were observed.
