[Impact of oxidative stress on the prevalence of hypercholesterolemia under the conditions of an industrial town].

The level of cholesterol and its distribution by the fractions of lipoproteins of different classes were studied in the dwellers of an industrial town. The persons living in the residential areas characterized by a high oxidative stress were observed to have higher blood cholesterol levels and dyslipoproteinemia.

[Free radical oxidation in the assessment of health risk].

Aliovalent metals (d-metals, such as manganese, nickel, iron, copper, chromium, etc.) which are able to change the degree of oxidation, to activate free radical oxidative processes, and to initiate the development of the condition that is currently defined as oxidative stress soundly and which are diagnostic criteria in the prenosological assessment of health risks are prominent among other priority ambient air pollutants. The findings suggest that there is a direct relationship between the calculated indices characterizing the carcinogenic and noncarcinogenic effects, the risk of oxidative stress, the environmental availability of prooxidants, mainly d-elements (manganese, nickel, copper, zinc) and the actual values of an increase in the rate of lipid peroxidation, of a decrease in antioxidative activity, and of an elevation in the level of methemoglobin formation.

[Unsolved questions of infectious endocarditis prophylaxis in outpatients practice]. / Nereshennye voprosy profilaktiki infektsionnogo éndokardita v ambulatornoi praktike.

AIM: To check practical feasibility of recommendations of prevention of infectious endocarditis (IE) and to provide more accurate figures on the occurrence of valvular lesions in working population. MATERIALS AND METHODS: Subacute IE manifestations have been analysed in 10 patients of a general outpatient clinic. Echocardiograms of 6209 patients under 60 years of age were studied retrospectively. RESULTS: In one-third of the patients IE developed in the presence of streptococcal and staphylococcal infection. In all the cases cardiac valve involvement was stated. In 4 cases changes in the valve were not accompanied my impairment of the valvular function. By echocardiography, valvular structure changes without valvular disease were detected 2.3 times more frequently that valvular disease. Difficulties presenting in outpatient IE prophylaxis are outlined. CONCLUSION: Advances in IE prevention will be achieved if echo-CG becomes a mandatory examination in the program of working population check-up, if early diagnosis of streptococcal ENT infection is made, if physicians of different specialties work as a team.