Reversible ischaemia after raising a radial forearm flap with ulceration of three fingers in a cigarette smoker.

The radial forearm flap is a standard method for the reconstruction of intraoral defects of soft tissues. We report the case of a middle-aged man who developed ischaemia in three fingers after a fasciocutaneous radial flap had been raised. The preoperative Allen test to diagnose occlusion of radial or ulnar artery was satisfactory. Soon after the operation the patient resumed smoking and four weeks later he developed ulcers on the thumb, index, and middle fingers. Only after he had stopped smoking and been given acetylsalicylic acid and heparin did blood flow and capillary hemoglobin oxygenation increase. As a result, his radial fingers recovered completely.

[Simultaneous noninvasive monitoring for radial forearm and fibula flaps using laser Doppler flowmetry and tissue spectrophotometry]. / Simultanes nichtinvasives Monitoring mit Laser-Doppler-Flussmessung und Gewebespektrometrie bei fasziokutanen Radialislappen und osteokutanen Fibulatransplantaten.

AIM: In the literature currently available monitoring devices are usually divided into two major groups: those for monitoring perfusion and those for measuring tissue oxygenation. The O(2)C (oxygen to see) system combines these two ways of monitoring free flap viability. The aim of this prospective study was to determine the necessity of flap revision and when unnecessary revision can be avoided. Another point of interest was the question of whether critical values for the successful course of free flaps could be defined and in addition whether such values would differ for different flap types. PATIENTS AND METHODS: In a prospective study 82 free flaps (61 radial forearm flaps and 21 fibula flaps) were monitored with the O(2)C monitoring unit. Measurements were carried out intraoperatively and postoperatively up to 14 days. RESULTS: Perfusion compromise occurred in 12 (14.6%) of 82 monitored free flaps. Operative exploration was performed in seven cases, in five of them successfully. Five flaps (three radial forearm and two fibula flaps) were lost due to vascular compromise, which led to an overall success rate of 93.4%. Venous congestion was identified by a rapid increase in hemoglobin concentration of more than 30%. An abrupt decline of blood flow and hemoglobin oxygenation indicated arterial occlusion. Vascular complications were detected in all cases prior to clinical assessment with no false positive or negative results. For radial forearm flaps a hemoglobin oxygenation of 15%, a superficial flow of 10 AU, and a deep flow of 20 AU were identified as minimum values for flap viability. For fibula flaps a hemoglobin oxygenation of 10%, a superficial flow of 5 AU, and a deep flow of 15 AU were determined as minimum values. CONCLUSION: O(2)C combines laser Doppler flowmetry and tissue spectrophotometry and for the first time allows simultaneous measurement of the microcirculatory parameters including blood flow, flow velocity, hemoglobin concentration, and hemoglobin oxygenation. We found this new noninvasive technique to be a reliable and accurate method for evaluating flap viability and improving the success rate in free flap transfer.

[Management of zygomatic fractures via a transconjunctival approach with lateral canthotomy while preserving the lateral ligament]. / Versorgung von Jochbeinfrakturen über einen transkonjunktivalen Zugang mit lateraler Kanthotomie unter Schonung des lateralen Lidbandes.

INTRODUCTION: This study reports on a modified approach to treat zygomatic fracture. For the surgical approach, a transconjunctival incision and, instead of a lateral canthotomy, a superficial incision of the skin and subcutaneous tissue was used, preserving the lateral ligament. The results are compared with those of previous techniques, especially the subciliary incision. PATIENTS: In a prospective study, 30 patients (9 females and 21 males, mean age 32.1 years) with zygomatic fractures were operated using this approach. Mean follow-up time was 6 months after removal of the plates. Fractures were caused by trauma due to fighting, bicycle falls, or sport accidents. Follow-up radiographs were used to evaluate the position of the zygoma after reduction and rigid fixation. RESULTS: Reduction and rigid fixation of the fractures were possible to perform in all cases. The access to the orbital floor and the exposure of the inferior and lateral rim were satisfactory and an additional latero-orbital cut was not necessary. The disadvantage of the complete incision of the lateral ligament with the necessity of intraoperative refixation and possible ectropium of the eyelid could be avoided. Injuries or infections of the cornea or the bulbus did not occur. Postoperative complications such as scar formation resulting in entropium or ectropium were not seen. CONCLUSION: These results show that the transconjunctival approach with lateral superficial incision preserving the lateral ligament for treatment of zygomatic fractures is satisfactory in all cases of rigid fixation of both inferior and lateral rims. Because of its esthetic and functional advantages this approach has become standard in our department.

[Oxygen-carrying solutions improve tissue oxygenation in striated skin muscle subjected to critical ischemia]. / Sauerstoff tragende Lösungen verbessern die Gewebeoxygenation im quergestreiften Hautmuskel nach kritischer Ischämiezeit.

AIM: The aim of the present study was to investigate the effects of the oxygen-carrying hemoglobin solution DCLHb (diaspirin-crosslinked hemoglobin) on microvascular perfusion and tissue oxygenation in striated skin muscle after the induction of critical ischemia followed by reperfusion. MATERIAL AND METHODS: Using intravital fluorescence microscopy the functional capillary density was analyzed in the striated skin muscle of Syrian golden hamsters before the induction of a 4-h period of ischemia and again after 0.5 h, 2 h and 24 h of reperfusion ( n=8 in each group). In other animals ( n=8 in each group), the identical protocol was applied to determine tissue oxygenation by means of the multi-wire surface electrode (MDO, Eschweiler, Kiel, Germany). Animals in the treatment group ( n=8) received a bolus infusion of 5 ml of DCLHb per kg of body wt. (10 g/dl; Baxter, Ill., USA) 15 min before reperfusion. Control animals ( n=8) received equivalent volumes of isotonic saline (Braun, Melsungen, Germany). RESULTS. Functional capillary density was dramatically reduced in control animals, while in DCLHb-treated animals significantly higher values were observed. Efficient restoration of tissue PO(2) was also seen in DCLHb-treated animals and not in control animals. CONCLUSIONS: These results show that the oxygen-carrying solution DCLHb is significantly more efficient than the commonly used crystalloid solutions in restoration of tissue PO(2) after ischemia-reperfusion. The use of this solution therefore appears promising as a means of protecting the tissue put at risk by ischemia from reperfusion damage.

Intravascular ultrasound Doppler measurement of blood flow velocity.

BACKGROUND AND PURPOSE: The authors investigated the feasibility and accuracy of intravascular Doppler sonography (IVDS) with a newly developed microprobe. METHODS: The known method to determine blood flow velocity by transcutaneous Doppler sonography was transferred to an intravascular usable Doppler probe. With the improved technique, a microprobe measuring 0.3 mm in diameter can be advanced through a 5F catheter used in routine diagnostic angiography to perform intravascular Doppler sonography. In a first step, the conditions for application and measurement were studied in a flow tube model and were transferred in a second step to patients undergoing routine angiography and patients with arterial stenoses. RESULTS: Measurements with nondegassed liquids showed a high intensive acoustic signal, but no echo effect could be recorded in degassed liquids. IVDS of healthy vessels in 40 patients showed the same typical flow pulse curve as seen in transcutaneous measurements. The optimal position of the microprobe with respect to the contact of the vessel wall, the diastolic and systolic phase, and the distance to the tip of the catheter could be evaluated. In 95.6% of the 40 patients with healthy vessels, IVDS was successful. Fourteen patients with arterial stenotic diseases were investigated before and after percutaneous transluminal angioplasty, and the results of these investigations correlated well with the angiographical results. CONCLUSIONS: For percutaneously directly reachable vessels, the transcutaneous Doppler sonography is the choice for easy noninvasive and inexpensive measurement of blood flow velocity. However, for vessels that are difficult or impossible to reach percutaneously, intravascular measurement is a valid procedure.

Gamma knife treatment of refractory cluster headache.

Four men and two women were treated for refractory cluster headache by gamma knife radiosurgery of the trigeminal nerve root entry zone. The maximum dose of radiation was 70 Gy to the isocenter. Of five patients treated who had refractory chronic cluster headache and one with refractory episodic cluster headache, four had relief judged excellent. Of the two remaining patients with refractory chronic cluster headache, one had relief judged good and the other fair. Five of the six patients treated had relief within a few days to a week following gamma knife radiosurgery. Three with chronic cluster headache had remissions allowing cessation of all preventive and abortive medication. Although one patient experienced complete relief of chronic cluster headache, he continued to have migraine requiring medication. None of the patients treated developed significant postradiation side effects during a follow-up period of 8 to 14 months. The authors conclude that gamma knife radiosurgery of the trigeminal nerve affords great promise in the management of chronic and refractory cluster headache. The technique seemingly carries negligible short- and long- term risk.

Evaluation and management of spontaneous temporal bone cerebrospinal fluid leaks.

Spontaneous temporal bone cerebrospinal fluid leak may be defined as a leak without an apparent precipitating cause. These transdural fistulas occur rarely, and diagnosis is predicated upon a high index of suspicion. Leaks have been reported through both middle and posterior fossa defects, although the vast majority involve the middle fossa plate. In a previous study we reported 7 cases of spontaneous temporal bone cerebrospinal fluid leaks, all involving the middle fossa tegmen. Upon further review of these cases and 5 previously unreported cases, the defect was localized to the tegmen tympani in 9 of the total 12 cases. Diagnostic methods are discussed, with the importance of high-resolution computed tomography stressed. The role of contrast cisternography is also evaluated. An outline for surgical management is presented based upon residual hearing and defect location and accessibility. A transmastoid procedure offers the advantage of visualization of both the middle and posterior fossa plates, and this approach can be supplemented with an obliterative procedure when indicated. The middle fossa approach provides optimal exposure of the tegmen plate with less likelihood of ossicular injury when dealing with tegmen tympani defects. Adjuncts to surgical therapy include intrathecal fluorescein dye and continuous postoperative lumbar cerebrospinal fluid drainage.

Indirect injury of the optic nerve.

Visual loss due to optic nerve injury after closed head trauma constitutes a formidable diagnostic and therapeutic challenge for the clinician. Assessment must be made of the site of optic nerve injury, and this is often difficult in the patient with an altered level of consciousness. A decision regarding optic nerve decompression must be formulated, yet the literature is confusing with regard to operative indications. In reviewing current pathogenetic theories, clinicopathological data, and therapeutic options, this report attempts to clarify the role of surgical intervention in indirect optic nerve injury.

Pneumocephalus secondary to spontaneous bronchial-subarachnoid fistula.

We describe a patient in whom pneumocephalus appeared spontaneously, resulting from a communication between the bronchial tree and the thoracic subarachnoid space in association with squamous cell carcinoma of the lung. The communication was demonstrated by myelography and obliterated surgically. A review of the literature is included.

Malignant and benign papillary lesions of the breast.

This presentation describes criteria that we found most helpful in classifying the various proliferative changes of the breast and in separating papillary carcinoma from other benign papillary lesions. The criteria we used are easily understood and extremely reproducible. The true incidence of benign proliferative changes in fibrocystic disease and the significance of these lesions in later development of cancer were determined by studying 200 randomly selected cases of fibrocystic disease seen at least 10 years earlier. Of the 200 cases of fibrocystic disease, 40 showed intraductal papillomatosis or terminal duct hyperplasia. None of the patients with benign proliferative lesions for whom we have complete follow-up data (up to 14 years) developed cancer. In order to determine the type of proliferating cells in papillary carcinoma and benign proliferative lesions, some of the recently encountered cases were studied by transmission and scanning electron microscopy and histochemistry. Our ultrastructural and histochemical study suggests that both epithelial and myoepithelial cells participate in papillary lesions of the breast.