RESUMO
IL7 regulates T cell survival, differentiation and proliferation. The alpha chain of its receptor, CD127, is polymorphic, and its haplotypes are associated with recovery from transplantation and with the autoimmune disease multiple sclerosis (MS), especially primary progressive MS (PPMS). We demonstrate that two CD127 haplotypes are highly associated with the proportion of the mRNA encoding the soluble isoform of CD127 (PAssuntos
Haplótipos
, Esclerose Múltipla/genética
, Neutrófilos/metabolismo
, Receptores de Interleucina-7/genética
, Células Th1/metabolismo
, Alelos
, Estudos de Casos e Controles
, Estudos de Coortes
, Feminino
, Expressão Gênica
, Heterozigoto
, Humanos
, Masculino
, RNA Mensageiro/metabolismo
, Estatística como Assunto